A new strategy for improving cytotoxicity of a copper complex toward metastatic melanoma cells unveiled by EPR spectroscopy

A novel strategy of improving cytotoxicity against metastatic melanoma cells using an oxindolimine copper(ii) complex immobilized and dimerized on a modified Polyhedral Oligomeric Silsesquioxane (POSS) matrix was developed, as revealed by electron paramagnetic resonance (EPR) spectroscopy. An assure...

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Autores principales: Vieira, Eduardo Guimarães, Fazzi, Rodrigo Boni, Martins, Daniel O. T. A., Sheveleva, Alena M., Tuna, Floriana, da Costa Ferreira, Ana Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038224/
https://www.ncbi.nlm.nih.gov/pubmed/36968063
http://dx.doi.org/10.1039/d2ra07266a
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author Vieira, Eduardo Guimarães
Fazzi, Rodrigo Boni
Martins, Daniel O. T. A.
Sheveleva, Alena M.
Tuna, Floriana
da Costa Ferreira, Ana Maria
author_facet Vieira, Eduardo Guimarães
Fazzi, Rodrigo Boni
Martins, Daniel O. T. A.
Sheveleva, Alena M.
Tuna, Floriana
da Costa Ferreira, Ana Maria
author_sort Vieira, Eduardo Guimarães
collection PubMed
description A novel strategy of improving cytotoxicity against metastatic melanoma cells using an oxindolimine copper(ii) complex immobilized and dimerized on a modified Polyhedral Oligomeric Silsesquioxane (POSS) matrix was developed, as revealed by electron paramagnetic resonance (EPR) spectroscopy. An assured correlation between continuous-wave (CW) and pulsed EPR spectroscopies provided a complete characterization of the actual active species, its coordination environment, as well as the efficiency/selectivity of the bioconjugate materials.
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spelling pubmed-100382242023-03-25 A new strategy for improving cytotoxicity of a copper complex toward metastatic melanoma cells unveiled by EPR spectroscopy Vieira, Eduardo Guimarães Fazzi, Rodrigo Boni Martins, Daniel O. T. A. Sheveleva, Alena M. Tuna, Floriana da Costa Ferreira, Ana Maria RSC Adv Chemistry A novel strategy of improving cytotoxicity against metastatic melanoma cells using an oxindolimine copper(ii) complex immobilized and dimerized on a modified Polyhedral Oligomeric Silsesquioxane (POSS) matrix was developed, as revealed by electron paramagnetic resonance (EPR) spectroscopy. An assured correlation between continuous-wave (CW) and pulsed EPR spectroscopies provided a complete characterization of the actual active species, its coordination environment, as well as the efficiency/selectivity of the bioconjugate materials. The Royal Society of Chemistry 2023-03-24 /pmc/articles/PMC10038224/ /pubmed/36968063 http://dx.doi.org/10.1039/d2ra07266a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Vieira, Eduardo Guimarães
Fazzi, Rodrigo Boni
Martins, Daniel O. T. A.
Sheveleva, Alena M.
Tuna, Floriana
da Costa Ferreira, Ana Maria
A new strategy for improving cytotoxicity of a copper complex toward metastatic melanoma cells unveiled by EPR spectroscopy
title A new strategy for improving cytotoxicity of a copper complex toward metastatic melanoma cells unveiled by EPR spectroscopy
title_full A new strategy for improving cytotoxicity of a copper complex toward metastatic melanoma cells unveiled by EPR spectroscopy
title_fullStr A new strategy for improving cytotoxicity of a copper complex toward metastatic melanoma cells unveiled by EPR spectroscopy
title_full_unstemmed A new strategy for improving cytotoxicity of a copper complex toward metastatic melanoma cells unveiled by EPR spectroscopy
title_short A new strategy for improving cytotoxicity of a copper complex toward metastatic melanoma cells unveiled by EPR spectroscopy
title_sort new strategy for improving cytotoxicity of a copper complex toward metastatic melanoma cells unveiled by epr spectroscopy
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038224/
https://www.ncbi.nlm.nih.gov/pubmed/36968063
http://dx.doi.org/10.1039/d2ra07266a
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