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External validation of geriatric influenza death score: A multicenter study

The Geriatric Influenza Death (GID) score was developed to help decision making in older patients with influenza in the emergency department (ED), but external validation is unavailable. Thus, we conducted a study was to fill the data gap. We recruited all older patients (≥65 years) who visited the...

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Autores principales: Kao, Yuan, Lee, Wei-Jing, Tsai, Kang-Ting, Liu, Chung-Feng, Hsu, Chien-Chin, Lin, Hung-Jung, Huang, Chien-Cheng, Guo, How-Ran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038296/
https://www.ncbi.nlm.nih.gov/pubmed/36961810
http://dx.doi.org/10.1371/journal.pone.0283475
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author Kao, Yuan
Lee, Wei-Jing
Tsai, Kang-Ting
Liu, Chung-Feng
Hsu, Chien-Chin
Lin, Hung-Jung
Huang, Chien-Cheng
Guo, How-Ran
author_facet Kao, Yuan
Lee, Wei-Jing
Tsai, Kang-Ting
Liu, Chung-Feng
Hsu, Chien-Chin
Lin, Hung-Jung
Huang, Chien-Cheng
Guo, How-Ran
author_sort Kao, Yuan
collection PubMed
description The Geriatric Influenza Death (GID) score was developed to help decision making in older patients with influenza in the emergency department (ED), but external validation is unavailable. Thus, we conducted a study was to fill the data gap. We recruited all older patients (≥65 years) who visited the ED of three hospitals between 2009 and 2018. Demographic data and clinical characteristics were retrospectively collected. Discrimination, goodness of fit, and performance of the GID score were evaluated. Of the 5,508 patients (121 died) with influenza, the mean age was 76.6±7.4 (standard deviation) years, and 49.3% were males. The GID score was higher in the mortality group (1.7±1.1 vs. 0.8±0.8, p <0.01). With 0 as the reference, the odds ratio for morality with score of 1, 2 and ≥3 was 3.08 (95% confidence interval [CI]: 1.66–5.71), 6.69 (95% CI: 3.52–12.71), and 23.68 (95% CI: 11.95–46.93), respectively. The area under the curve was 0.722 (95% CI: 0.677–0.766), and the Hosmer–Lemeshow goodness of fit test was 1.000. The GID score had excellent negative predictive values with different cut-offs. The GID score had good external validity, and further studies are warranted for wider application.
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spelling pubmed-100382962023-03-25 External validation of geriatric influenza death score: A multicenter study Kao, Yuan Lee, Wei-Jing Tsai, Kang-Ting Liu, Chung-Feng Hsu, Chien-Chin Lin, Hung-Jung Huang, Chien-Cheng Guo, How-Ran PLoS One Research Article The Geriatric Influenza Death (GID) score was developed to help decision making in older patients with influenza in the emergency department (ED), but external validation is unavailable. Thus, we conducted a study was to fill the data gap. We recruited all older patients (≥65 years) who visited the ED of three hospitals between 2009 and 2018. Demographic data and clinical characteristics were retrospectively collected. Discrimination, goodness of fit, and performance of the GID score were evaluated. Of the 5,508 patients (121 died) with influenza, the mean age was 76.6±7.4 (standard deviation) years, and 49.3% were males. The GID score was higher in the mortality group (1.7±1.1 vs. 0.8±0.8, p <0.01). With 0 as the reference, the odds ratio for morality with score of 1, 2 and ≥3 was 3.08 (95% confidence interval [CI]: 1.66–5.71), 6.69 (95% CI: 3.52–12.71), and 23.68 (95% CI: 11.95–46.93), respectively. The area under the curve was 0.722 (95% CI: 0.677–0.766), and the Hosmer–Lemeshow goodness of fit test was 1.000. The GID score had excellent negative predictive values with different cut-offs. The GID score had good external validity, and further studies are warranted for wider application. Public Library of Science 2023-03-24 /pmc/articles/PMC10038296/ /pubmed/36961810 http://dx.doi.org/10.1371/journal.pone.0283475 Text en © 2023 Kao et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kao, Yuan
Lee, Wei-Jing
Tsai, Kang-Ting
Liu, Chung-Feng
Hsu, Chien-Chin
Lin, Hung-Jung
Huang, Chien-Cheng
Guo, How-Ran
External validation of geriatric influenza death score: A multicenter study
title External validation of geriatric influenza death score: A multicenter study
title_full External validation of geriatric influenza death score: A multicenter study
title_fullStr External validation of geriatric influenza death score: A multicenter study
title_full_unstemmed External validation of geriatric influenza death score: A multicenter study
title_short External validation of geriatric influenza death score: A multicenter study
title_sort external validation of geriatric influenza death score: a multicenter study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038296/
https://www.ncbi.nlm.nih.gov/pubmed/36961810
http://dx.doi.org/10.1371/journal.pone.0283475
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