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Inflammatory CD4/CD8 double-positive human T cells arise from reactive CD8 T cells and are sufficient to mediate GVHD pathology

An important paradigm in allogeneic hematopoietic cell transplantations (allo-HCTs) is the prevention of graft-versus-host disease (GVHD) while preserving the graft-versus-leukemia (GVL) activity of donor T cells. From an observational clinical study of adult allo-HCT recipients, we identified a CD4...

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Detalles Bibliográficos
Autores principales:	Hess, Nicholas J., Turicek, David P., Riendeau, Jeremiah, McIlwain, Sean J., Contreras Guzman, Emmanuel, Nadiminti, Kalyan, Hudson, Amy, Callander, Natalie S., Skala, Melissa C., Gumperz, Jenny E., Hematti, Peiman, Capitini, Christian M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2023
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038349/ https://www.ncbi.nlm.nih.gov/pubmed/36961891 http://dx.doi.org/10.1126/sciadv.adf0567

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