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Dating the origin and spread of specialization on human hosts in Aedes aegypti mosquitoes
The globally invasive mosquito subspecies Aedes aegypti aegypti is an effective vector of human arboviruses, in part because it specializes in biting humans and breeding in human habitats. Recent work suggests that specialization first arose as an adaptation to long, hot dry seasons in the West Afri...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038657/ https://www.ncbi.nlm.nih.gov/pubmed/36897062 http://dx.doi.org/10.7554/eLife.83524 |
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author | Rose, Noah H Badolo, Athanase Sylla, Massamba Akorli, Jewelna Otoo, Sampson Gloria-Soria, Andrea Powell, Jeffrey R White, Bradley J Crawford, Jacob E McBride, Carolyn S |
author_facet | Rose, Noah H Badolo, Athanase Sylla, Massamba Akorli, Jewelna Otoo, Sampson Gloria-Soria, Andrea Powell, Jeffrey R White, Bradley J Crawford, Jacob E McBride, Carolyn S |
author_sort | Rose, Noah H |
collection | PubMed |
description | The globally invasive mosquito subspecies Aedes aegypti aegypti is an effective vector of human arboviruses, in part because it specializes in biting humans and breeding in human habitats. Recent work suggests that specialization first arose as an adaptation to long, hot dry seasons in the West African Sahel, where Ae. aegypti relies on human-stored water for breeding. Here, we use whole-genome cross-coalescent analysis to date the emergence of human-specialist populationsand thus further probe the climate hypothesis. Importantly, we take advantage of the known migration of specialists out of Africa during the Atlantic Slave Trade to calibrate the coalescent clock and thus obtain a more precise estimate of the older evolutionary event than would otherwise be possible. We find that human-specialist mosquitoes diverged rapidly from ecological generalists approximately 5000 years ago, at the end of the African Humid Period—a time when the Sahara dried and water stored by humans became a uniquely stable, aquatic niche in the Sahel. We also use population genomic analyses to date a previously observed influx of human-specialist alleles into major West African cities. The characteristic length of tracts of human-specialist ancestry present on a generalist genetic background in Kumasi and Ouagadougou suggests the change in behavior occurred during rapid urbanization over the last 20–40 years. Taken together, we show that the timing and ecological context of two previously observed shifts towards human biting in Ae. aegypti differ; climate was likely the original driver, but urbanization has become increasingly important in recent decades. |
format | Online Article Text |
id | pubmed-10038657 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-100386572023-03-25 Dating the origin and spread of specialization on human hosts in Aedes aegypti mosquitoes Rose, Noah H Badolo, Athanase Sylla, Massamba Akorli, Jewelna Otoo, Sampson Gloria-Soria, Andrea Powell, Jeffrey R White, Bradley J Crawford, Jacob E McBride, Carolyn S eLife Evolutionary Biology The globally invasive mosquito subspecies Aedes aegypti aegypti is an effective vector of human arboviruses, in part because it specializes in biting humans and breeding in human habitats. Recent work suggests that specialization first arose as an adaptation to long, hot dry seasons in the West African Sahel, where Ae. aegypti relies on human-stored water for breeding. Here, we use whole-genome cross-coalescent analysis to date the emergence of human-specialist populationsand thus further probe the climate hypothesis. Importantly, we take advantage of the known migration of specialists out of Africa during the Atlantic Slave Trade to calibrate the coalescent clock and thus obtain a more precise estimate of the older evolutionary event than would otherwise be possible. We find that human-specialist mosquitoes diverged rapidly from ecological generalists approximately 5000 years ago, at the end of the African Humid Period—a time when the Sahara dried and water stored by humans became a uniquely stable, aquatic niche in the Sahel. We also use population genomic analyses to date a previously observed influx of human-specialist alleles into major West African cities. The characteristic length of tracts of human-specialist ancestry present on a generalist genetic background in Kumasi and Ouagadougou suggests the change in behavior occurred during rapid urbanization over the last 20–40 years. Taken together, we show that the timing and ecological context of two previously observed shifts towards human biting in Ae. aegypti differ; climate was likely the original driver, but urbanization has become increasingly important in recent decades. eLife Sciences Publications, Ltd 2023-03-10 /pmc/articles/PMC10038657/ /pubmed/36897062 http://dx.doi.org/10.7554/eLife.83524 Text en © 2023, Rose et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Evolutionary Biology Rose, Noah H Badolo, Athanase Sylla, Massamba Akorli, Jewelna Otoo, Sampson Gloria-Soria, Andrea Powell, Jeffrey R White, Bradley J Crawford, Jacob E McBride, Carolyn S Dating the origin and spread of specialization on human hosts in Aedes aegypti mosquitoes |
title | Dating the origin and spread of specialization on human hosts in Aedes aegypti mosquitoes |
title_full | Dating the origin and spread of specialization on human hosts in Aedes aegypti mosquitoes |
title_fullStr | Dating the origin and spread of specialization on human hosts in Aedes aegypti mosquitoes |
title_full_unstemmed | Dating the origin and spread of specialization on human hosts in Aedes aegypti mosquitoes |
title_short | Dating the origin and spread of specialization on human hosts in Aedes aegypti mosquitoes |
title_sort | dating the origin and spread of specialization on human hosts in aedes aegypti mosquitoes |
topic | Evolutionary Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038657/ https://www.ncbi.nlm.nih.gov/pubmed/36897062 http://dx.doi.org/10.7554/eLife.83524 |
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