HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation

Tristetraprolin (TTP) is a critical negative immune regulator. It binds AU-rich elements in the untranslated-regions of many mRNAs encoding pro-inflammatory mediators, thereby accelerating their decay. A key but poorly understood mechanism of TTP regulation is its timely proteolytic removal: TTP is...

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Detalles Bibliográficos
Autores principales: Scinicariello, Sara, Soderholm, Adrian, Schäfer, Markus, Shulkina, Alexandra, Schwartz, Irene, Hacker, Kathrin, Gogova, Rebeca, Kalis, Robert, Froussios, Kimon, Budroni, Valentina, Bestehorn, Annika, Clausen, Tim, Kovarik, Pavel, Zuber, Johannes, Versteeg, Gijs A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038661/
https://www.ncbi.nlm.nih.gov/pubmed/36961408
http://dx.doi.org/10.7554/eLife.83159

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