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The Significance of the Nucleic Acid Test (NAT) to Prevent Viral Contamination in Musculoskeletal Tissue Transplantation
Objective The present study aims to highlight the significance of the nucleic acid test (NAT) for musculoskeletal tissue donation and to compare the sensitivity of this test on the different available platforms. Method The present study is a retrospective survey in a human tissue bank database and...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Thieme Revinter Publicações Ltda.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038709/ https://www.ncbi.nlm.nih.gov/pubmed/36969792 http://dx.doi.org/10.1055/s-0042-1756156 |
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author | Corsi, Carlos Alexandre Curylofo Luiz, Alan Vinicius Assunção Cintra, Álefe Saloum Scarpelini, Katia Carmen Gabriel Bento, Rodolfo Leandro Garcia, Flávio Luis Picado, Celso Herminio Ferraz Martins, Luís Gustavo Gazoni |
author_facet | Corsi, Carlos Alexandre Curylofo Luiz, Alan Vinicius Assunção Cintra, Álefe Saloum Scarpelini, Katia Carmen Gabriel Bento, Rodolfo Leandro Garcia, Flávio Luis Picado, Celso Herminio Ferraz Martins, Luís Gustavo Gazoni |
author_sort | Corsi, Carlos Alexandre Curylofo |
collection | PubMed |
description | Objective The present study aims to highlight the significance of the nucleic acid test (NAT) for musculoskeletal tissue donation and to compare the sensitivity of this test on the different available platforms. Method The present study is a retrospective survey in a human tissue bank database and an integrative literature review encompassing the last 10 years. The PubMed portal and the SCOPUS, CINAHL, and Web of Science databases were queried for articles. Results We found no specific studies on the use and sensitivity of NAT in braindead tissue donors. The information presented in the present study consists of specific contents intended for the Brazilian Blood Transfusion Network (Hemorrede Transfusional Nacional, in Portuguese) and internal retrospective data from a tissue bank located at a city in the state of São Paulo, Brazil. Conclusions The NAT is effective in blood samples from living patients. However, since biochemical reactions in braindead patients can be different, specific research, platforms, or both are crucial to tissue banks. |
format | Online Article Text |
id | pubmed-10038709 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Thieme Revinter Publicações Ltda. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100387092023-03-25 The Significance of the Nucleic Acid Test (NAT) to Prevent Viral Contamination in Musculoskeletal Tissue Transplantation Corsi, Carlos Alexandre Curylofo Luiz, Alan Vinicius Assunção Cintra, Álefe Saloum Scarpelini, Katia Carmen Gabriel Bento, Rodolfo Leandro Garcia, Flávio Luis Picado, Celso Herminio Ferraz Martins, Luís Gustavo Gazoni Rev Bras Ortop (Sao Paulo) Objective The present study aims to highlight the significance of the nucleic acid test (NAT) for musculoskeletal tissue donation and to compare the sensitivity of this test on the different available platforms. Method The present study is a retrospective survey in a human tissue bank database and an integrative literature review encompassing the last 10 years. The PubMed portal and the SCOPUS, CINAHL, and Web of Science databases were queried for articles. Results We found no specific studies on the use and sensitivity of NAT in braindead tissue donors. The information presented in the present study consists of specific contents intended for the Brazilian Blood Transfusion Network (Hemorrede Transfusional Nacional, in Portuguese) and internal retrospective data from a tissue bank located at a city in the state of São Paulo, Brazil. Conclusions The NAT is effective in blood samples from living patients. However, since biochemical reactions in braindead patients can be different, specific research, platforms, or both are crucial to tissue banks. Thieme Revinter Publicações Ltda. 2022-10-13 /pmc/articles/PMC10038709/ /pubmed/36969792 http://dx.doi.org/10.1055/s-0042-1756156 Text en Sociedade Brasileira de Ortopedia e Traumatologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited. |
spellingShingle | Corsi, Carlos Alexandre Curylofo Luiz, Alan Vinicius Assunção Cintra, Álefe Saloum Scarpelini, Katia Carmen Gabriel Bento, Rodolfo Leandro Garcia, Flávio Luis Picado, Celso Herminio Ferraz Martins, Luís Gustavo Gazoni The Significance of the Nucleic Acid Test (NAT) to Prevent Viral Contamination in Musculoskeletal Tissue Transplantation |
title | The Significance of the Nucleic Acid Test (NAT) to Prevent Viral Contamination in Musculoskeletal Tissue Transplantation |
title_full | The Significance of the Nucleic Acid Test (NAT) to Prevent Viral Contamination in Musculoskeletal Tissue Transplantation |
title_fullStr | The Significance of the Nucleic Acid Test (NAT) to Prevent Viral Contamination in Musculoskeletal Tissue Transplantation |
title_full_unstemmed | The Significance of the Nucleic Acid Test (NAT) to Prevent Viral Contamination in Musculoskeletal Tissue Transplantation |
title_short | The Significance of the Nucleic Acid Test (NAT) to Prevent Viral Contamination in Musculoskeletal Tissue Transplantation |
title_sort | significance of the nucleic acid test (nat) to prevent viral contamination in musculoskeletal tissue transplantation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038709/ https://www.ncbi.nlm.nih.gov/pubmed/36969792 http://dx.doi.org/10.1055/s-0042-1756156 |
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