cMyBP-C ablation in human engineered cardiac tissue causes progressive Ca(2+)-handling abnormalities

Truncation mutations in cardiac myosin binding protein C (cMyBP-C) are common causes of hypertrophic cardiomyopathy (HCM). Heterozygous carriers present with classical HCM, while homozygous carriers present with early onset HCM that rapidly progress to heart failure. We used CRISPR-Cas9 to introduce...

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Detalles Bibliográficos
Autores principales: De Lange, Willem J., Farrell, Emily T., Hernandez, Jonathan J., Stempien, Alana, Kreitzer, Caroline R., Jacobs, Derek R., Petty, Dominique L., Moss, Richard L., Crone, Wendy C., Ralphe, J. Carter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038829/
https://www.ncbi.nlm.nih.gov/pubmed/36893011
http://dx.doi.org/10.1085/jgp.202213204

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