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Diagnostic delay in adult inflammatory bowel disease: A systematic review
BACKGROUND: The extent of diagnostic delay in inflammatory bowel disease (IBD) is incompletely understood. We aimed to understand the extent of diagnostic delay of IBD in adults and identify associations between patient or healthcare characteristics and length of delay. METHODS: Articles were source...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer India
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038954/ https://www.ncbi.nlm.nih.gov/pubmed/36715839 http://dx.doi.org/10.1007/s12664-022-01303-x |
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author | Cross, Eleanor Saunders, Benjamin Farmer, Adam D. Prior, James A. |
author_facet | Cross, Eleanor Saunders, Benjamin Farmer, Adam D. Prior, James A. |
author_sort | Cross, Eleanor |
collection | PubMed |
description | BACKGROUND: The extent of diagnostic delay in inflammatory bowel disease (IBD) is incompletely understood. We aimed to understand the extent of diagnostic delay of IBD in adults and identify associations between patient or healthcare characteristics and length of delay. METHODS: Articles were sourced from EMBASE, Medline and CINAHL from inception to April 2021. Inclusion criteria were adult cohorts (18 ≥ years old) reporting median time periods between onset of symptoms for Crohn’s disease (CD), ulcerative colitis (UC) or IBD (i.e. CD and UC together) and a final diagnosis (diagnostic delay). Narrative synthesis was used to examine the extent of diagnostic delay and characteristics associated with delay. Sensitivity analysis was applied by the removal of outliers. RESULTS: Thirty-one articles reporting median diagnostic delay for IBD, CD or UC were included. After sensitivity analysis, the majority of IBD studies (7 of 8) reported a median delay of between 2 and 5.3 months. From the studies examining median delay in UC, three-quarters (12 of 16) reported a delay between 2 and 6 months. In contrast, three-quarters of the CD studies (17 of 23) reported a delay of between 2 and 12 months. No characteristic had been examined enough to understand their role in diagnostic delay in these populations. CONCLUSIONS: This systematic review provides robust insight into the extent of diagnostic delay in IBD and suggests further intervention is needed to reduce delay in CD particularly. Furthermore, our findings provide a benchmark value range for diagnostic delay, which such future work can be measured against. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12664-022-01303-x. |
format | Online Article Text |
id | pubmed-10038954 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer India |
record_format | MEDLINE/PubMed |
spelling | pubmed-100389542023-03-26 Diagnostic delay in adult inflammatory bowel disease: A systematic review Cross, Eleanor Saunders, Benjamin Farmer, Adam D. Prior, James A. Indian J Gastroenterol Original Article BACKGROUND: The extent of diagnostic delay in inflammatory bowel disease (IBD) is incompletely understood. We aimed to understand the extent of diagnostic delay of IBD in adults and identify associations between patient or healthcare characteristics and length of delay. METHODS: Articles were sourced from EMBASE, Medline and CINAHL from inception to April 2021. Inclusion criteria were adult cohorts (18 ≥ years old) reporting median time periods between onset of symptoms for Crohn’s disease (CD), ulcerative colitis (UC) or IBD (i.e. CD and UC together) and a final diagnosis (diagnostic delay). Narrative synthesis was used to examine the extent of diagnostic delay and characteristics associated with delay. Sensitivity analysis was applied by the removal of outliers. RESULTS: Thirty-one articles reporting median diagnostic delay for IBD, CD or UC were included. After sensitivity analysis, the majority of IBD studies (7 of 8) reported a median delay of between 2 and 5.3 months. From the studies examining median delay in UC, three-quarters (12 of 16) reported a delay between 2 and 6 months. In contrast, three-quarters of the CD studies (17 of 23) reported a delay of between 2 and 12 months. No characteristic had been examined enough to understand their role in diagnostic delay in these populations. CONCLUSIONS: This systematic review provides robust insight into the extent of diagnostic delay in IBD and suggests further intervention is needed to reduce delay in CD particularly. Furthermore, our findings provide a benchmark value range for diagnostic delay, which such future work can be measured against. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12664-022-01303-x. Springer India 2023-01-30 2023 /pmc/articles/PMC10038954/ /pubmed/36715839 http://dx.doi.org/10.1007/s12664-022-01303-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Cross, Eleanor Saunders, Benjamin Farmer, Adam D. Prior, James A. Diagnostic delay in adult inflammatory bowel disease: A systematic review |
title | Diagnostic delay in adult inflammatory bowel disease: A systematic review |
title_full | Diagnostic delay in adult inflammatory bowel disease: A systematic review |
title_fullStr | Diagnostic delay in adult inflammatory bowel disease: A systematic review |
title_full_unstemmed | Diagnostic delay in adult inflammatory bowel disease: A systematic review |
title_short | Diagnostic delay in adult inflammatory bowel disease: A systematic review |
title_sort | diagnostic delay in adult inflammatory bowel disease: a systematic review |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038954/ https://www.ncbi.nlm.nih.gov/pubmed/36715839 http://dx.doi.org/10.1007/s12664-022-01303-x |
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