Cargando…

LNA blockers for improved amplification selectivity

LNA-containing oligonucleotides bind DNA more tightly than standard DNA, so they can interact with targeted sequences and affect multiple processes. When a desired DNA is present at low concentrations relative to nearly identical undesired DNAs, LNAs can block amplification of unwanted DNAs. Using a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Prout, Jaime, Tian, Michael, Palladino, Alicia, Wright, Jason, Thompson, John F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038989/ https://www.ncbi.nlm.nih.gov/pubmed/36964235 http://dx.doi.org/10.1038/s41598-023-31871-7

Ejemplares similares

Amplification and Re-Generation of LNA-Modified Libraries
por: Doessing, Holger, et al.
Publicado: (2012)

Design of LNA probes that improve mismatch discrimination
por: You, Yong, et al.
Publicado: (2006)

Improvements in Bacterial Primers to Enhance Selective SSU rRNA Gene Amplification of Plant-associated Bacteria by Applying the LNA Oligonucleotide-PCR Clamping Technique
por: Ikenaga, Makoto, et al.
Publicado: (2018)

Systemic Evaluation of Chimeric LNA/2′-O-Methyl Steric Blockers for Myotonic Dystrophy Type 1 Therapy
por: Christou, Melina, et al.
Publicado: (2020)

Application of Locked Nucleic Acid (LNA) Primer and PCR Clamping by LNA Oligonucleotide to Enhance the Amplification of Internal Transcribed Spacer (ITS) Regions in Investigating the Community Structures of Plant–Associated Fungi
por: Ikenaga, Makoto, et al.
Publicado: (2016)

Kinetic Hairpin Oligonucleotide Blockers for Selective Amplification of Rare Mutations
por: Jia, Yanwei, et al.
Publicado: (2014)

Electronic Structures of LNA Phosphorothioate Oligonucleotides
por: Bohr, Henrik G., et al.
Publicado: (2017)

Targeting LDL Cholesterol With LNA
por: Krieg, Arthur M
Publicado: (2012)

Novel Methodology for Rapid Detection of KRAS Mutation Using PNA-LNA Mediated Loop-Mediated Isothermal Amplification
por: Itonaga, Masahiro, et al.
Publicado: (2016)

Stimulation of ribosomal frameshifting by antisense LNA
por: Yu, Chien-Hung, et al.
Publicado: (2010)

Towards Zwitterionic Oligonucleotides with Improved Properties: the NAA/LNA‐Gapmer Approach
por: Wojtyniak, Melissa, et al.
Publicado: (2020)

Toehold-enhanced LNA probes for selective pull down and single-molecule analysis of native chromatin
por: Hermans, Nicolaas, et al.
Publicado: (2017)

Mapping the nicking efficiencies of nickase R.BbvCI for side-specific LNA-substituted substrates using rolling circle amplification
por: Wei, Hua, et al.
Publicado: (2016)

Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality
por: Elmén, Joacim, et al.
Publicado: (2005)

An Inductorless Gain-Controllable Wideband LNA Based on CCCIIs
por: Wan, Qiuzhen, et al.
Publicado: (2022)

Refining LNA safety profile by controlling phosphorothioate stereochemistry
por: Funder, Erik Daa, et al.
Publicado: (2020)

Synthesis of Oligonucleotides Containing 2′-N-alkylaminocarbonyl-2′-amino-LNA (2′-urea-LNA) Moieties Using Post-Synthetic Modification Strategy
por: Yamashita, Shoko, et al.
Publicado: (2020)

NMR solution structures of LNA (locked nucleic acid) modified quadruplexes
por: Nielsen, Jakob T., et al.
Publicado: (2006)

LNA-enhanced DNA FIT-probes for multicolour RNA imaging
por: Hövelmann, F., et al.
Publicado: (2016)

Optimizing anti-gene oligonucleotide ‘Zorro-LNA’ for improved strand invasion into duplex DNA
por: Zaghloul, Eman M., et al.
Publicado: (2011)

Towards the controlled enzymatic synthesis of LNA containing oligonucleotides
por: Sabat, Nazarii, et al.
Publicado: (2023)

Specific RNP capture with antisense LNA/DNA mixmers
por: Rogell, Birgit, et al.
Publicado: (2017)

Miniature Wide-Band Noise-Canceling CMOS LNA †
por: Galante-Sempere, David, et al.
Publicado: (2022)

Position-dependent effects of locked nucleic acid (LNA) on DNA sequencing and PCR primers
por: Levin, Joshua D., et al.
Publicado: (2006)

DISSECT Method Using PNA-LNA Clamp Improves Detection of EGFR T790m Mutation
por: Guha, Minakshi, et al.
Publicado: (2013)

Specificity of RNAi, LNA and CRISPRi as loss-of-function methods in transcriptional analysis
por: Stojic, Lovorka, et al.
Publicado: (2018)

Targeting sphingosine kinase 1 with LNA oligonucleotides in gastric cancer
por: Füreder, Thorsten, et al.
Publicado: (2008)

LNA units present in [R(P)-PS]-(DNA#LNA) chimeras enhance the thermal stability of parallel duplexes and triplexes formed with (2′-OMe)-RNA strands
por: Jastrzębska, Katarzyna, et al.
Publicado: (2020)

LNA probes substantially improve the detection of bacterial endosymbionts in whole mount of insects by fluorescent in-situ hybridization
por: Priya, Natarajan Gayatri, et al.
Publicado: (2012)

EGFR Mutation Analysis of Circulating Tumor DNA Using an Improved PNA-LNA PCR Clamp Method
por: Watanabe, Kana, et al.
Publicado: (2016)

Failure Mechanism of pHEMT in Navigation LNA under UWB EMP
por: Li, Yonglong, et al.
Publicado: (2022)

Investigating discovery strategies and pharmacological properties of stereodefined phosphorodithioate LNA gapmers
por: Duschmalé, Jörg, et al.
Publicado: (2022)

An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides
por: Baker, Ysobel R., et al.
Publicado: (2022)

Synthesis and Biophysical Properties of C5-Functionalized LNA (Locked Nucleic Acid)
por: Kumar, Pawan, et al.
Publicado: (2014)

Sub-cellular temporal and spatial distribution of electrotransferred LNA/DNA oligomer
por: Orio, Julie, et al.
Publicado: (2013)

Locked nucleic acid (LNA): High affinity targeting of RNA for diagnostics and therapeutics
por: Kauppinen, Sakari, et al.
Publicado: (2005)

Can Vitamin B12 Assist the Internalization of Antisense LNA Oligonucleotides into Bacteria?
por: Pereira, Sara, et al.
Publicado: (2021)

Investigation on Temperature Behavior for a GaAs E-pHEMT MMIC LNA
por: Lin, Qian, et al.
Publicado: (2022)

Efficient inhibition of HIV-1 expression by LNA modified antisense oligonucleotides and DNAzymes targeted to functionally selected binding sites
por: Jakobsen, Martin R, et al.
Publicado: (2007)

Investigation of catalysis by bacterial RNase P via LNA and other modifications at the scissile phosphodiester
por: Cuzic-Feltens, Simona, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_e7gqu646p9g1epbdjk3n55celo