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Recurrent activity in neuronal avalanches
A new statistical analysis of large neuronal avalanches observed in mouse and rat brain tissues reveals a substantial degree of recurrent activity and cyclic patterns of activation not seen in smaller avalanches. To explain these observations, we adapted a model of structural weakening in materials....
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039060/ https://www.ncbi.nlm.nih.gov/pubmed/36964158 http://dx.doi.org/10.1038/s41598-023-31851-x |
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author | Salners, Tyler Avila, Karina E. Nicholson, Benjamin Myers, Christopher R. Beggs, John Dahmen, Karin A. |
author_facet | Salners, Tyler Avila, Karina E. Nicholson, Benjamin Myers, Christopher R. Beggs, John Dahmen, Karin A. |
author_sort | Salners, Tyler |
collection | PubMed |
description | A new statistical analysis of large neuronal avalanches observed in mouse and rat brain tissues reveals a substantial degree of recurrent activity and cyclic patterns of activation not seen in smaller avalanches. To explain these observations, we adapted a model of structural weakening in materials. In this model, dynamical weakening of neuron firing thresholds closely replicates experimental avalanche size distributions, firing number distributions, and patterns of cyclic activity. This agreement between model and data suggests that a mechanism like dynamical weakening plays a key role in recurrent activity found in large neuronal avalanches. We expect these results to illuminate the causes and dynamics of large avalanches, like those seen in seizures. |
format | Online Article Text |
id | pubmed-10039060 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-100390602023-03-26 Recurrent activity in neuronal avalanches Salners, Tyler Avila, Karina E. Nicholson, Benjamin Myers, Christopher R. Beggs, John Dahmen, Karin A. Sci Rep Article A new statistical analysis of large neuronal avalanches observed in mouse and rat brain tissues reveals a substantial degree of recurrent activity and cyclic patterns of activation not seen in smaller avalanches. To explain these observations, we adapted a model of structural weakening in materials. In this model, dynamical weakening of neuron firing thresholds closely replicates experimental avalanche size distributions, firing number distributions, and patterns of cyclic activity. This agreement between model and data suggests that a mechanism like dynamical weakening plays a key role in recurrent activity found in large neuronal avalanches. We expect these results to illuminate the causes and dynamics of large avalanches, like those seen in seizures. Nature Publishing Group UK 2023-03-24 /pmc/articles/PMC10039060/ /pubmed/36964158 http://dx.doi.org/10.1038/s41598-023-31851-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Salners, Tyler Avila, Karina E. Nicholson, Benjamin Myers, Christopher R. Beggs, John Dahmen, Karin A. Recurrent activity in neuronal avalanches |
title | Recurrent activity in neuronal avalanches |
title_full | Recurrent activity in neuronal avalanches |
title_fullStr | Recurrent activity in neuronal avalanches |
title_full_unstemmed | Recurrent activity in neuronal avalanches |
title_short | Recurrent activity in neuronal avalanches |
title_sort | recurrent activity in neuronal avalanches |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039060/ https://www.ncbi.nlm.nih.gov/pubmed/36964158 http://dx.doi.org/10.1038/s41598-023-31851-x |
work_keys_str_mv | AT salnerstyler recurrentactivityinneuronalavalanches AT avilakarinae recurrentactivityinneuronalavalanches AT nicholsonbenjamin recurrentactivityinneuronalavalanches AT myerschristopherr recurrentactivityinneuronalavalanches AT beggsjohn recurrentactivityinneuronalavalanches AT dahmenkarina recurrentactivityinneuronalavalanches |