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Safety of Lidocaine During Wide-Awake Local Anesthesia No Tourniquet for Distal Radius Plating

PURPOSE: This study evaluated the clinical and biochemical safety profile of infiltration of lidocaine with adrenaline in wide-awake local anesthesia no tourniquet for distal radius plating. METHODS: Twenty-four participants were randomly assigned to the therapeutic group (n = 19) (1% lidocaine in 1...

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Autores principales: Abdullah, Shalimar, Tokiran, Muhamad Fitri, Ahmad, Amir Adham, Soh, Elaine Zi Fan, Makpol, Suzana, Sapuan, Jamari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039303/
https://www.ncbi.nlm.nih.gov/pubmed/36974291
http://dx.doi.org/10.1016/j.jhsg.2022.12.003
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author Abdullah, Shalimar
Tokiran, Muhamad Fitri
Ahmad, Amir Adham
Soh, Elaine Zi Fan
Makpol, Suzana
Sapuan, Jamari
author_facet Abdullah, Shalimar
Tokiran, Muhamad Fitri
Ahmad, Amir Adham
Soh, Elaine Zi Fan
Makpol, Suzana
Sapuan, Jamari
author_sort Abdullah, Shalimar
collection PubMed
description PURPOSE: This study evaluated the clinical and biochemical safety profile of infiltration of lidocaine with adrenaline in wide-awake local anesthesia no tourniquet for distal radius plating. METHODS: Twenty-four participants were randomly assigned to the therapeutic group (n = 19) (1% lidocaine in 1:100,000 adrenaline) and control group (n = 5) (2% lidocaine alone). Clinical parameters, including skin necrosis, duration of recovery of sensation, and lidocaine toxicity, were monitored. The serum lidocaine level was measured at different time intervals using a high-performance liquid chromatography reagent. RESULTS: No lidocaine toxicity was recorded in any participant. The therapeutic group had a longer time for recovery of sensation. There was a significant difference in the serum lidocaine levels between both the groups at all time intervals up to 6 hours, with all participants exhibiting serum lidocaine levels below the mild toxicity level of 6.0 μg/mL. CONCLUSIONS: Lidocaine used within a safe recommended dose in wide-awake local anesthesia no tourniquet for distal radius plating is clinically and biochemically safe. CLINICAL RELEVANCE: Determining the clinical and biochemical safety profile of lidocaine with adrenaline in wide-awake local anesthesia no tourniquet can promote wider use of this technique.
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spelling pubmed-100393032023-03-26 Safety of Lidocaine During Wide-Awake Local Anesthesia No Tourniquet for Distal Radius Plating Abdullah, Shalimar Tokiran, Muhamad Fitri Ahmad, Amir Adham Soh, Elaine Zi Fan Makpol, Suzana Sapuan, Jamari J Hand Surg Glob Online Original Research PURPOSE: This study evaluated the clinical and biochemical safety profile of infiltration of lidocaine with adrenaline in wide-awake local anesthesia no tourniquet for distal radius plating. METHODS: Twenty-four participants were randomly assigned to the therapeutic group (n = 19) (1% lidocaine in 1:100,000 adrenaline) and control group (n = 5) (2% lidocaine alone). Clinical parameters, including skin necrosis, duration of recovery of sensation, and lidocaine toxicity, were monitored. The serum lidocaine level was measured at different time intervals using a high-performance liquid chromatography reagent. RESULTS: No lidocaine toxicity was recorded in any participant. The therapeutic group had a longer time for recovery of sensation. There was a significant difference in the serum lidocaine levels between both the groups at all time intervals up to 6 hours, with all participants exhibiting serum lidocaine levels below the mild toxicity level of 6.0 μg/mL. CONCLUSIONS: Lidocaine used within a safe recommended dose in wide-awake local anesthesia no tourniquet for distal radius plating is clinically and biochemically safe. CLINICAL RELEVANCE: Determining the clinical and biochemical safety profile of lidocaine with adrenaline in wide-awake local anesthesia no tourniquet can promote wider use of this technique. Elsevier 2023-01-09 /pmc/articles/PMC10039303/ /pubmed/36974291 http://dx.doi.org/10.1016/j.jhsg.2022.12.003 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research
Abdullah, Shalimar
Tokiran, Muhamad Fitri
Ahmad, Amir Adham
Soh, Elaine Zi Fan
Makpol, Suzana
Sapuan, Jamari
Safety of Lidocaine During Wide-Awake Local Anesthesia No Tourniquet for Distal Radius Plating
title Safety of Lidocaine During Wide-Awake Local Anesthesia No Tourniquet for Distal Radius Plating
title_full Safety of Lidocaine During Wide-Awake Local Anesthesia No Tourniquet for Distal Radius Plating
title_fullStr Safety of Lidocaine During Wide-Awake Local Anesthesia No Tourniquet for Distal Radius Plating
title_full_unstemmed Safety of Lidocaine During Wide-Awake Local Anesthesia No Tourniquet for Distal Radius Plating
title_short Safety of Lidocaine During Wide-Awake Local Anesthesia No Tourniquet for Distal Radius Plating
title_sort safety of lidocaine during wide-awake local anesthesia no tourniquet for distal radius plating
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039303/
https://www.ncbi.nlm.nih.gov/pubmed/36974291
http://dx.doi.org/10.1016/j.jhsg.2022.12.003
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