LZTFL1 inhibits kidney tumor cell growth by destabilizing AKT through ZNRF1-mediated ubiquitin proteosome pathway

LZTFL1 is a tumor suppressor located in chromosomal region 3p21.3 that is deleted frequently and early in various cancer types including the kidney cancer. However, its role in kidney tumorigenesis remains unknown. Here we hypothesized a tumor suppressive function of LZTFL1 in clear cell renal cell...

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Detalles Bibliográficos
Autores principales: Lu, Jun, Fu, Liang-min, Cao, Yun, Fang, Yong, Cao, Jia-zheng, Pan, Yi-hui, Cen, Jun-jie, Liang, Yan-ping, Chen, Zhen-hua, Wei, Jin-huan, Huang, Yong, Mumin, Mukhtar Adan, Xu, Quan-hui, Wang, Ying-han, Zhu, Jiang-quan, Liang, Hui, Wang, Zhu, Deng, Qiong, Chen, Wei, Jin, Xiao-han, Liu, Zhi-ping, Luo, Jun-hang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039360/
https://www.ncbi.nlm.nih.gov/pubmed/36966254
http://dx.doi.org/10.1038/s41388-023-02666-x

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