Cargando…

The Caribbean-Hispanic Alzheimer’s disease brain transcriptome reveals ancestry-specific disease mechanisms

Identifying ancestry-specific molecular profiles of late-onset Alzheimer’s Disease (LOAD) in brain tissue is crucial to understand novel mechanisms and develop effective interventions in non-European, high-risk populations. We performed gene differential expression (DE) and consensus network-based a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Felsky, Daniel, Santa-Maria, Ismael, Cosacak, Mehmet Ilyas, French, Leon, Schneider, Julie A., Bennett, David A., De Jager, Philip L., Kizil, Caghan, Tosto, Giuseppe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039465/ https://www.ncbi.nlm.nih.gov/pubmed/36462719 http://dx.doi.org/10.1016/j.nbd.2022.105938

Ejemplares similares

Single Cell/Nucleus Transcriptomics Comparison in Zebrafish and Humans Reveals Common and Distinct Molecular Responses to Alzheimer’s Disease
por: Cosacak, Mehmet Ilyas, et al.
Publicado: (2022)

Alzheimer’s disease, neural stem cells and neurogenesis: cellular phase at single-cell level
por: Cosacak, Mehmet Ilyas, et al.
Publicado: (2019)

Admixture Mapping of Alzheimer’s disease in Caribbean Hispanics identifies a new locus on 22q13.1
por: Kizil, Caghan, et al.
Publicado: (2022)

KYNA/Ahr Signaling Suppresses Neural Stem Cell Plasticity and Neurogenesis in Adult Zebrafish Model of Alzheimer’s Disease
por: Siddiqui, Tohid, et al.
Publicado: (2021)

Regeneration, Plasticity, and Induced Molecular Programs in Adult Zebrafish Brain
por: Cosacak, Mehmet Ilyas, et al.
Publicado: (2015)

Protocol for Dissection and Dissociation of Zebrafish Telencephalon for Single-Cell Sequencing
por: Cosacak, Mehmet Ilyas, et al.
Publicado: (2020)

Re-Arrangements in the Cytoplasmic Distribution of Small RNAs Following the Maternal-to-Zygotic Transition in Drosophila Embryos
por: Cosacak, Mehmet Ilyas, et al.
Publicado: (2018)

Ultra-rare mutations in SRCAP segregate in Caribbean Hispanic families with Alzheimer disease
por: Vardarajan, Badri N., et al.
Publicado: (2017)

sox1a:eGFP transgenic line and single-cell transcriptomics reveal the origin of zebrafish intraspinal serotonergic neurons
por: Chen, Fushun, et al.
Publicado: (2023)

Is Alzheimer’s Also a Stem Cell Disease? – The Zebrafish Perspective
por: Kizil, Caghan, et al.
Publicado: (2018)

Nerve growth factor receptor (Ngfr) induces neurogenic plasticity by suppressing reactive astroglial Lcn2/Slc22a17 signaling in Alzheimer’s disease
por: Siddiqui, Tohid, et al.
Publicado: (2023)

Whole genome sequencing of Caribbean Hispanic families with late‐onset Alzheimer's disease
por: Vardarajan, Badri N., et al.
Publicado: (2018)

Neuron-glia interaction through Serotonin-BDNF-NGFR axis enables regenerative neurogenesis in Alzheimer’s model of adult zebrafish brain
por: Bhattarai, Prabesh, et al.
Publicado: (2020)

Neural stem/progenitor cells in Alzheimer’s disease
por: Tincer, Gizem, et al.
Publicado: (2016)

Discovery of Ancestry-specific Variants Associated with Clopidogrel Response among Caribbean Hispanics
por: Yang, Guang, et al.
Publicado: (2023)

Admixture mapping reveals the association between Native American ancestry at 3q13.11 and reduced risk of Alzheimer’s disease in Caribbean Hispanics
por: Horimoto, Andréa R. V. R., et al.
Publicado: (2021)

RNA methyltransferase NSun2 deficiency promotes neurodegeneration through epitranscriptomic regulation of tau phosphorylation
por: Kim, Yoon A., et al.
Publicado: (2022)

Inbreeding among Caribbean Hispanics from the Dominican Republic and the Effects on the Risk of Alzheimer's Disease
por: Vardarajan, BN, et al.
Publicado: (2014)

Synonymous variants associated with Alzheimer disease in multiplex families
por: Tang, Min, et al.
Publicado: (2020)

[Hispanic Caribbean litarature]
por: González, Echeverría Roberto
Publicado: (1980)

Type 1 Interleukin-4 Signaling Obliterates Mouse Astroglia in vivo but Not in vitro
por: Mashkaryan, Violeta, et al.
Publicado: (2020)

Differentiation of Hispanic biogeographic ancestry with 80 ancestry informative markers
por: Setser, Casandra H., et al.
Publicado: (2020)

Bulk and Single-Nucleus Transcriptomics Highlight Intra-Telencephalic and Somatostatin Neurons in Alzheimer’s Disease
por: Consens, Micaela E., et al.
Publicado: (2022)

Genome-Wide Survey of Large Rare Copy Number Variants in Alzheimer’s Disease Among Caribbean Hispanics
por: Ghani, Mahdi, et al.
Publicado: (2012)

Evaluation of Plasma Biomarkers for A/T/N Classification of Alzheimer Disease Among Adults of Caribbean Hispanic Ethnicity
por: Honig, Lawrence S., et al.
Publicado: (2023)

Disease-related mutations among Caribbean Hispanics with familial dementia
por: Lee, Joseph H, et al.
Publicado: (2014)

Mechanisms of Pathology-Induced Neural Stem Cell Plasticity and Neural Regeneration in Adult Zebrafish Brain
por: Kizil, Caghan
Publicado: (2018)

Human TAU(P301L) overexpression results in TAU hyperphosphorylation without neurofibrillary tangles in adult zebrafish brain
por: Cosacak, Mehmet I., et al.
Publicado: (2017)

Skeletal Microstructure in Caribbean Hispanic Women
por: Agarwal, Sanchita, et al.
Publicado: (2023)

Admixture mapping implicates 13q33.3 as ancestry-of-origin locus for Alzheimer disease in Hispanic and Latino populations
por: Horimoto, Andrea R.V.R., et al.
Publicado: (2023)

Genome-wide interaction study of brain beta-amyloid burden and cognitive impairment in Alzheimer's disease
por: Roostaei, T, et al.
Publicado: (2017)

Donor-Specific Transcriptomic Analysis of Alzheimer's Disease-Associated Hypometabolism Highlights a Unique Donor, Ribosomal Proteins and Microglia
por: Patel, Sejal, et al.
Publicado: (2020)

Hispanic culture of Mexico, Central America, and the Caribbean /
Publicado: (1996)

Cerebroventricular Microinjection (CVMI) into Adult Zebrafish Brain Is an Efficient Misexpression Method for Forebrain Ventricular Cells
por: Kizil, Caghan, et al.
Publicado: (2011)

Glia-neuron interactions underlie state transitions to generalized seizures
por: Diaz Verdugo, Carmen, et al.
Publicado: (2019)

GATA3 Promotes the Neural Progenitor State but Not Neurogenesis in 3D Traumatic Injury Model of Primary Human Cortical Astrocytes
por: Celikkaya, Hilal, et al.
Publicado: (2019)

Linkage analysis of multiplex Caribbean Hispanic families loaded for unexplained early-onset cases identifies novel Alzheimer's disease loci
por: Cheng, Rong, et al.
Publicado: (2018)

Local Ancestry Inference in a Large US-Based Hispanic/Latino Study: Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
por: Browning, Sharon R., et al.
Publicado: (2016)

The neuropathological landscape of Hispanic and non-Hispanic White decedents with Alzheimer disease
por: Scalco, Rebeca, et al.
Publicado: (2023)

FMNL2 regulates gliovascular interactions and is associated with vascular risk factors and cerebrovascular pathology in Alzheimer’s disease
por: Lee, Annie J., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_4o62rjl0op6qhk14q35ce2jot2