Exploration of lung mycobiome in the patients with non-small-cell lung cancer

As the Human Microbiome Project (HMP) progresses, the relationship between microbes and human health has been receiving increasing attention. A growing number of reports support the correlation between cancer and microbes. However, most studies have focused on bacteria, rather than fungal communitie...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Yiming, Yi, Junqi, Xiang, Juanjuan, Jia, Wei, Chen, Anqi, Chen, Liyu, Zheng, Leliang, Zhou, Wen, Wu, Minghua, Yu, Zheng, Tang, Jingqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039514/
https://www.ncbi.nlm.nih.gov/pubmed/36966280
http://dx.doi.org/10.1186/s12866-023-02790-4
_version_ 1784912284497215488
author Zhao, Yiming
Yi, Junqi
Xiang, Juanjuan
Jia, Wei
Chen, Anqi
Chen, Liyu
Zheng, Leliang
Zhou, Wen
Wu, Minghua
Yu, Zheng
Tang, Jingqun
author_facet Zhao, Yiming
Yi, Junqi
Xiang, Juanjuan
Jia, Wei
Chen, Anqi
Chen, Liyu
Zheng, Leliang
Zhou, Wen
Wu, Minghua
Yu, Zheng
Tang, Jingqun
author_sort Zhao, Yiming
collection PubMed
description As the Human Microbiome Project (HMP) progresses, the relationship between microbes and human health has been receiving increasing attention. A growing number of reports support the correlation between cancer and microbes. However, most studies have focused on bacteria, rather than fungal communities. In this study, we studied the alteration in lung mycobiome in patients with non-small-cell lung cancer (NSCLC) using metagenomic sequencing and qPCR. The higher fungal diversity and more complex network were observed in the patients with NSCLC. In addition, Alternaria arborescens was found as the most relevant fungus to NSCLC, and the enrichment of it in cancerous tissue was also detected. This study proposes that the changes in fungal communities may be closely related to lung cancer, and provides insights into further exploration the relationship between lung cancer and fungi. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12866-023-02790-4
format Online
Article
Text
id pubmed-10039514
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-100395142023-03-26 Exploration of lung mycobiome in the patients with non-small-cell lung cancer Zhao, Yiming Yi, Junqi Xiang, Juanjuan Jia, Wei Chen, Anqi Chen, Liyu Zheng, Leliang Zhou, Wen Wu, Minghua Yu, Zheng Tang, Jingqun BMC Microbiol Research As the Human Microbiome Project (HMP) progresses, the relationship between microbes and human health has been receiving increasing attention. A growing number of reports support the correlation between cancer and microbes. However, most studies have focused on bacteria, rather than fungal communities. In this study, we studied the alteration in lung mycobiome in patients with non-small-cell lung cancer (NSCLC) using metagenomic sequencing and qPCR. The higher fungal diversity and more complex network were observed in the patients with NSCLC. In addition, Alternaria arborescens was found as the most relevant fungus to NSCLC, and the enrichment of it in cancerous tissue was also detected. This study proposes that the changes in fungal communities may be closely related to lung cancer, and provides insights into further exploration the relationship between lung cancer and fungi. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12866-023-02790-4 BioMed Central 2023-03-25 /pmc/articles/PMC10039514/ /pubmed/36966280 http://dx.doi.org/10.1186/s12866-023-02790-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Zhao, Yiming
Yi, Junqi
Xiang, Juanjuan
Jia, Wei
Chen, Anqi
Chen, Liyu
Zheng, Leliang
Zhou, Wen
Wu, Minghua
Yu, Zheng
Tang, Jingqun
Exploration of lung mycobiome in the patients with non-small-cell lung cancer
title Exploration of lung mycobiome in the patients with non-small-cell lung cancer
title_full Exploration of lung mycobiome in the patients with non-small-cell lung cancer
title_fullStr Exploration of lung mycobiome in the patients with non-small-cell lung cancer
title_full_unstemmed Exploration of lung mycobiome in the patients with non-small-cell lung cancer
title_short Exploration of lung mycobiome in the patients with non-small-cell lung cancer
title_sort exploration of lung mycobiome in the patients with non-small-cell lung cancer
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039514/
https://www.ncbi.nlm.nih.gov/pubmed/36966280
http://dx.doi.org/10.1186/s12866-023-02790-4
work_keys_str_mv AT zhaoyiming explorationoflungmycobiomeinthepatientswithnonsmallcelllungcancer
AT yijunqi explorationoflungmycobiomeinthepatientswithnonsmallcelllungcancer
AT xiangjuanjuan explorationoflungmycobiomeinthepatientswithnonsmallcelllungcancer
AT jiawei explorationoflungmycobiomeinthepatientswithnonsmallcelllungcancer
AT chenanqi explorationoflungmycobiomeinthepatientswithnonsmallcelllungcancer
AT chenliyu explorationoflungmycobiomeinthepatientswithnonsmallcelllungcancer
AT zhengleliang explorationoflungmycobiomeinthepatientswithnonsmallcelllungcancer
AT zhouwen explorationoflungmycobiomeinthepatientswithnonsmallcelllungcancer
AT wuminghua explorationoflungmycobiomeinthepatientswithnonsmallcelllungcancer
AT yuzheng explorationoflungmycobiomeinthepatientswithnonsmallcelllungcancer
AT tangjingqun explorationoflungmycobiomeinthepatientswithnonsmallcelllungcancer

Ejemplares similares