Longitudinal DNA methylation profiling of the rectal mucosa identifies cell-specific signatures of disease status, severity and clinical outcomes in ulcerative colitis cell-specific DNA methylation signatures of UC

BACKGROUND: In peripheral blood, DNA methylation (DNAm) patterns in inflammatory bowel disease patients reflect inflammatory status rather than disease status. Here, we examined DNAm in diseased rectal mucosa from ulcerative colitis (UC) patients, focusing on constituent cell types with the goal of...

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Detalles Bibliográficos
Autores principales: Venkateswaran, Suresh, Somineni, Hari K., Matthews, Jason D., Kilaru, Varun, Hyams, Jeffrey S., Denson, Lee A., Kellamayer, Richard, Gibson, Greg, Cutler, David J., Conneely, Karen N., Smith, Alicia K., Kugathasan, Subra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039532/
https://www.ncbi.nlm.nih.gov/pubmed/36964596
http://dx.doi.org/10.1186/s13148-023-01462-4

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