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Cerebral Aβ deposition precedes reduced cerebrospinal fluid and serum Aβ42/Aβ40 ratios in the App(NL−F/NL−F) knock-in mouse model of Alzheimer’s disease

BACKGROUND: Aβ42/Aβ40 ratios in cerebrospinal fluid (CSF) and blood are reduced in preclinical Alzheimer’s disease (AD), but their temporal and correlative relationship with cerebral Aβ pathology at this early disease stage is not well understood. In the present study, we aim to investigate such rel...

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Detalles Bibliográficos
Autores principales:	Andersson, Emelie, Schultz, Nina, Saito, Takashi, Saido, Takaomi C., Blennow, Kaj, Gouras, Gunnar K., Zetterberg, Henrik, Hansson, Oskar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039589/ https://www.ncbi.nlm.nih.gov/pubmed/36964585 http://dx.doi.org/10.1186/s13195-023-01196-8

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