Cargando…
The Antibacterial Effect, Biocompatibility, and Osteogenesis of Vancomycin-Nanodiamond Composite Scaffold for Infected Bone Defects
PURPOSE: The repair and treatment of infected bone defects (IBD) is a common challenge faced by orthopedic clinics, medical materials science, and tissue engineering. METHODS: Based on the treatment requirements of IBD, we utilized multidisciplinary knowledge from clinical medicine, medical material...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039664/ https://www.ncbi.nlm.nih.gov/pubmed/36974073 http://dx.doi.org/10.2147/IJN.S397316 |
_version_ | 1784912317224321024 |
---|---|
author | Chen, Meng Li, Yang Hou, Wen-Xiu Peng, Da-Yong Li, Jing-Kun Zhang, Hao-Xuan |
author_facet | Chen, Meng Li, Yang Hou, Wen-Xiu Peng, Da-Yong Li, Jing-Kun Zhang, Hao-Xuan |
author_sort | Chen, Meng |
collection | PubMed |
description | PURPOSE: The repair and treatment of infected bone defects (IBD) is a common challenge faced by orthopedic clinics, medical materials science, and tissue engineering. METHODS: Based on the treatment requirements of IBD, we utilized multidisciplinary knowledge from clinical medicine, medical materials science, and tissue engineering to construct a high-efficiency vancomycin sustained-release system with nanodiamond (ND) and prepare a composite scaffold. Its effect on IBD treatment was assessed from materials, cytology, bacteriology, and zoology perspectives. RESULTS: The results demonstrated that the Van-ND-45S5 scaffold exhibited an excellent antibacterial effect, biocompatibility, and osteogenesis in vitro. Moreover, an efficient animal model of IBD was established, and a Van-ND-45S5 scaffold was implanted into the IBD. Radiographic and histological analyses and bone repair-related protein expression, confirmed that the Van-ND-45S5 scaffold had good biocompatibility and osteogenic and anti-infective activities in vivo. CONCLUSION: Collectively, our findings support that the Van-ND-45S5 scaffold is a promising new material and approach for treating IBD with good antibacterial effects, biocompatibility, and osteogenesis. |
format | Online Article Text |
id | pubmed-10039664 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-100396642023-03-26 The Antibacterial Effect, Biocompatibility, and Osteogenesis of Vancomycin-Nanodiamond Composite Scaffold for Infected Bone Defects Chen, Meng Li, Yang Hou, Wen-Xiu Peng, Da-Yong Li, Jing-Kun Zhang, Hao-Xuan Int J Nanomedicine Original Research PURPOSE: The repair and treatment of infected bone defects (IBD) is a common challenge faced by orthopedic clinics, medical materials science, and tissue engineering. METHODS: Based on the treatment requirements of IBD, we utilized multidisciplinary knowledge from clinical medicine, medical materials science, and tissue engineering to construct a high-efficiency vancomycin sustained-release system with nanodiamond (ND) and prepare a composite scaffold. Its effect on IBD treatment was assessed from materials, cytology, bacteriology, and zoology perspectives. RESULTS: The results demonstrated that the Van-ND-45S5 scaffold exhibited an excellent antibacterial effect, biocompatibility, and osteogenesis in vitro. Moreover, an efficient animal model of IBD was established, and a Van-ND-45S5 scaffold was implanted into the IBD. Radiographic and histological analyses and bone repair-related protein expression, confirmed that the Van-ND-45S5 scaffold had good biocompatibility and osteogenic and anti-infective activities in vivo. CONCLUSION: Collectively, our findings support that the Van-ND-45S5 scaffold is a promising new material and approach for treating IBD with good antibacterial effects, biocompatibility, and osteogenesis. Dove 2023-03-21 /pmc/articles/PMC10039664/ /pubmed/36974073 http://dx.doi.org/10.2147/IJN.S397316 Text en © 2023 Chen et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Chen, Meng Li, Yang Hou, Wen-Xiu Peng, Da-Yong Li, Jing-Kun Zhang, Hao-Xuan The Antibacterial Effect, Biocompatibility, and Osteogenesis of Vancomycin-Nanodiamond Composite Scaffold for Infected Bone Defects |
title | The Antibacterial Effect, Biocompatibility, and Osteogenesis of Vancomycin-Nanodiamond Composite Scaffold for Infected Bone Defects |
title_full | The Antibacterial Effect, Biocompatibility, and Osteogenesis of Vancomycin-Nanodiamond Composite Scaffold for Infected Bone Defects |
title_fullStr | The Antibacterial Effect, Biocompatibility, and Osteogenesis of Vancomycin-Nanodiamond Composite Scaffold for Infected Bone Defects |
title_full_unstemmed | The Antibacterial Effect, Biocompatibility, and Osteogenesis of Vancomycin-Nanodiamond Composite Scaffold for Infected Bone Defects |
title_short | The Antibacterial Effect, Biocompatibility, and Osteogenesis of Vancomycin-Nanodiamond Composite Scaffold for Infected Bone Defects |
title_sort | antibacterial effect, biocompatibility, and osteogenesis of vancomycin-nanodiamond composite scaffold for infected bone defects |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039664/ https://www.ncbi.nlm.nih.gov/pubmed/36974073 http://dx.doi.org/10.2147/IJN.S397316 |
work_keys_str_mv | AT chenmeng theantibacterialeffectbiocompatibilityandosteogenesisofvancomycinnanodiamondcompositescaffoldforinfectedbonedefects AT liyang theantibacterialeffectbiocompatibilityandosteogenesisofvancomycinnanodiamondcompositescaffoldforinfectedbonedefects AT houwenxiu theantibacterialeffectbiocompatibilityandosteogenesisofvancomycinnanodiamondcompositescaffoldforinfectedbonedefects AT pengdayong theantibacterialeffectbiocompatibilityandosteogenesisofvancomycinnanodiamondcompositescaffoldforinfectedbonedefects AT lijingkun theantibacterialeffectbiocompatibilityandosteogenesisofvancomycinnanodiamondcompositescaffoldforinfectedbonedefects AT zhanghaoxuan theantibacterialeffectbiocompatibilityandosteogenesisofvancomycinnanodiamondcompositescaffoldforinfectedbonedefects AT chenmeng antibacterialeffectbiocompatibilityandosteogenesisofvancomycinnanodiamondcompositescaffoldforinfectedbonedefects AT liyang antibacterialeffectbiocompatibilityandosteogenesisofvancomycinnanodiamondcompositescaffoldforinfectedbonedefects AT houwenxiu antibacterialeffectbiocompatibilityandosteogenesisofvancomycinnanodiamondcompositescaffoldforinfectedbonedefects AT pengdayong antibacterialeffectbiocompatibilityandosteogenesisofvancomycinnanodiamondcompositescaffoldforinfectedbonedefects AT lijingkun antibacterialeffectbiocompatibilityandosteogenesisofvancomycinnanodiamondcompositescaffoldforinfectedbonedefects AT zhanghaoxuan antibacterialeffectbiocompatibilityandosteogenesisofvancomycinnanodiamondcompositescaffoldforinfectedbonedefects |