Anti-Glutamic Acid Decarboxylase (GAD) 65 Encephalitis Mistaken for Herpes Encephalitis and Hashimoto’s Encephalitis (HE): A Case Report

Autoimmune encephalitis is increasingly recognized in clinical practice. We are presenting a 72-year-old female patient who initially presented with a new onset seizure with temporal lobe abnormality on imaging. This was initially attributed to herpes encephalitis although herpes polymerase chain reaction (PCR) was negative. The patient was treated with acyclovir and antiepileptic medication (AEM) with some clinical improvement. She presented again with refractory seizure evolving to status epilepticus. Escalation of AEMs was pursued and positive anti-thyroid peroxidase (TPO) antibody prompted consideration of Hashimoto’s encephalitis (HE) and treatment with high-dose corticosteroids and intravenous immunoglobulin (IVIG). However, poor response to steroid argued against HE, and extended autoimmune encephalitis panel revealed positive anti-glutamic acid decarboxylase (GAD) antibody. This case raises the clinical pearl that anti-thyroid antibodies, e.g anti-TPO antibody, can be seen in those with autoimmune encephalopathies other than HE and HE remains a diagnosis of exclusion. It also helps to remind clinicians that a new onset refractory seizure even with temporal lobe changes is not pathognomonic for herpes encephalitis, and although negative serology does not rule out the diagnosis, it is recommended to rule out autoimmune encephalitis as it shares similar clinical and radiological picture.