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A computational overview of integrase strand transfer inhibitors (INSTIs) against emerging and evolving drug-resistant HIV-1 integrase mutants

AIDS (Acquired immunodeficiency syndrome) is one of the chronic and potentially life-threatening epidemics across the world. Hitherto, the non-existence of definitive drugs that could completely cure the Human immunodeficiency virus (HIV) implies an urgent necessity for the discovery of novel anti-H...

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Autores principales: Sayyed, Sharif Karim, Quraishi, Marzuqa, Jobby, Renitta, Rameshkumar, Neelamegam, Kayalvizhi, Nagarajan, Krishnan, Muthukalingan, Sonawane, Tareeka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039815/
https://www.ncbi.nlm.nih.gov/pubmed/36966200
http://dx.doi.org/10.1007/s00203-023-03461-8
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author Sayyed, Sharif Karim
Quraishi, Marzuqa
Jobby, Renitta
Rameshkumar, Neelamegam
Kayalvizhi, Nagarajan
Krishnan, Muthukalingan
Sonawane, Tareeka
author_facet Sayyed, Sharif Karim
Quraishi, Marzuqa
Jobby, Renitta
Rameshkumar, Neelamegam
Kayalvizhi, Nagarajan
Krishnan, Muthukalingan
Sonawane, Tareeka
author_sort Sayyed, Sharif Karim
collection PubMed
description AIDS (Acquired immunodeficiency syndrome) is one of the chronic and potentially life-threatening epidemics across the world. Hitherto, the non-existence of definitive drugs that could completely cure the Human immunodeficiency virus (HIV) implies an urgent necessity for the discovery of novel anti-HIV agents. Since integration is the most crucial stage in retroviral replication, hindering it can inhibit overall viral transmission. The 5 FDA-approved integrase inhibitors were computationally investigated, especially owing to the rising multiple mutations against their susceptibility. This comparative study will open new possibilities to guide the rational design of novel lead compounds for antiretroviral therapies (ARTs), more specifically the structure-based design of novel Integrase strand transfer inhibitors (INSTIs) that may possess a better resistance profile than present drugs. Further, we have discussed potent anti-HIV natural compounds and their interactions as an alternative approach, recommending the urgent need to tap into the rich vein of indigenous knowledge for reverse pharmacology. Moreover, herein, we discuss existing evidence that might change in the near future. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00203-023-03461-8.
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spelling pubmed-100398152023-03-27 A computational overview of integrase strand transfer inhibitors (INSTIs) against emerging and evolving drug-resistant HIV-1 integrase mutants Sayyed, Sharif Karim Quraishi, Marzuqa Jobby, Renitta Rameshkumar, Neelamegam Kayalvizhi, Nagarajan Krishnan, Muthukalingan Sonawane, Tareeka Arch Microbiol Mini Review AIDS (Acquired immunodeficiency syndrome) is one of the chronic and potentially life-threatening epidemics across the world. Hitherto, the non-existence of definitive drugs that could completely cure the Human immunodeficiency virus (HIV) implies an urgent necessity for the discovery of novel anti-HIV agents. Since integration is the most crucial stage in retroviral replication, hindering it can inhibit overall viral transmission. The 5 FDA-approved integrase inhibitors were computationally investigated, especially owing to the rising multiple mutations against their susceptibility. This comparative study will open new possibilities to guide the rational design of novel lead compounds for antiretroviral therapies (ARTs), more specifically the structure-based design of novel Integrase strand transfer inhibitors (INSTIs) that may possess a better resistance profile than present drugs. Further, we have discussed potent anti-HIV natural compounds and their interactions as an alternative approach, recommending the urgent need to tap into the rich vein of indigenous knowledge for reverse pharmacology. Moreover, herein, we discuss existing evidence that might change in the near future. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00203-023-03461-8. Springer Berlin Heidelberg 2023-03-26 2023 /pmc/articles/PMC10039815/ /pubmed/36966200 http://dx.doi.org/10.1007/s00203-023-03461-8 Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Mini Review
Sayyed, Sharif Karim
Quraishi, Marzuqa
Jobby, Renitta
Rameshkumar, Neelamegam
Kayalvizhi, Nagarajan
Krishnan, Muthukalingan
Sonawane, Tareeka
A computational overview of integrase strand transfer inhibitors (INSTIs) against emerging and evolving drug-resistant HIV-1 integrase mutants
title A computational overview of integrase strand transfer inhibitors (INSTIs) against emerging and evolving drug-resistant HIV-1 integrase mutants
title_full A computational overview of integrase strand transfer inhibitors (INSTIs) against emerging and evolving drug-resistant HIV-1 integrase mutants
title_fullStr A computational overview of integrase strand transfer inhibitors (INSTIs) against emerging and evolving drug-resistant HIV-1 integrase mutants
title_full_unstemmed A computational overview of integrase strand transfer inhibitors (INSTIs) against emerging and evolving drug-resistant HIV-1 integrase mutants
title_short A computational overview of integrase strand transfer inhibitors (INSTIs) against emerging and evolving drug-resistant HIV-1 integrase mutants
title_sort computational overview of integrase strand transfer inhibitors (instis) against emerging and evolving drug-resistant hiv-1 integrase mutants
topic Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039815/
https://www.ncbi.nlm.nih.gov/pubmed/36966200
http://dx.doi.org/10.1007/s00203-023-03461-8
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