Endogenous bioluminescent reporters reveal a sustained increase in utrophin gene expression upon EZH2 and ERK1/2 inhibition

Duchenne muscular dystrophy (DMD) is an X-linked disorder caused by loss of function mutations in the dystrophin gene (Dmd), resulting in progressive muscle weakening. Here we modelled the longitudinal expression of endogenous Dmd, and its paralogue Utrn, in mice and in myoblasts by generating bespo...

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Detalles Bibliográficos
Autores principales: Gleneadie, Hannah J., Fernandez-Ruiz, Beatriz, Sardini, Alessandro, Van de Pette, Mathew, Dimond, Andrew, Prinjha, Rab K., McGinty, James, French, Paul M. W., Bagci, Hakan, Merkenschlager, Matthias, Fisher, Amanda G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039851/
https://www.ncbi.nlm.nih.gov/pubmed/36966198
http://dx.doi.org/10.1038/s42003-023-04666-9

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