Unnatural activities and mechanistic insights of cytochrome P450 PikC gained from site-specific mutagenesis by non-canonical amino acids

Cytochrome P450 enzymes play important roles in the biosynthesis of macrolide antibiotics by mediating a vast variety of regio- and stereoselective oxidative modifications, thus improving their chemical diversity, biological activities, and pharmaceutical properties. Tremendous efforts have been mad...

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Detalles Bibliográficos
Autores principales: Pan, Yunjun, Li, Guobang, Liu, Ruxin, Guo, Jiawei, Liu, Yunjie, Liu, Mingyu, Zhang, Xingwang, Chi, Luping, Xu, Kangwei, Wu, Ruibo, Zhang, Yuzhong, Li, Yuezhong, Gao, Xiang, Li, Shengying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039885/
https://www.ncbi.nlm.nih.gov/pubmed/36966128
http://dx.doi.org/10.1038/s41467-023-37288-0

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