Integrative proteogenomic characterization of early esophageal cancer

Esophageal squamous cell carcinoma (ESCC) is malignant while the carcinogenesis is still unclear. Here, we perform a comprehensive multi-omics analysis of 786 trace-tumor-samples from 154 ESCC patients, covering 9 histopathological stages and 3 phases. Proteogenomics elucidates cancer-driving waves...

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Autores principales: Li, Lingling, Jiang, Dongxian, Zhang, Qiao, Liu, Hui, Xu, Fujiang, Guo, Chunmei, Qin, Zhaoyu, Wang, Haixing, Feng, Jinwen, Liu, Yang, Chen, Weijie, Zhang, Xue, Bai, Lin, Tian, Sha, Tan, Subei, Xu, Chen, Song, Qi, Liu, Yalan, Zhong, Yunshi, Chen, Tianyin, Zhou, Pinghong, Zhao, Jian-Yuan, Hou, Yingyong, Ding, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039899/
https://www.ncbi.nlm.nih.gov/pubmed/36966136
http://dx.doi.org/10.1038/s41467-023-37440-w
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author Li, Lingling
Jiang, Dongxian
Zhang, Qiao
Liu, Hui
Xu, Fujiang
Guo, Chunmei
Qin, Zhaoyu
Wang, Haixing
Feng, Jinwen
Liu, Yang
Chen, Weijie
Zhang, Xue
Bai, Lin
Tian, Sha
Tan, Subei
Xu, Chen
Song, Qi
Liu, Yalan
Zhong, Yunshi
Chen, Tianyin
Zhou, Pinghong
Zhao, Jian-Yuan
Hou, Yingyong
Ding, Chen
author_facet Li, Lingling
Jiang, Dongxian
Zhang, Qiao
Liu, Hui
Xu, Fujiang
Guo, Chunmei
Qin, Zhaoyu
Wang, Haixing
Feng, Jinwen
Liu, Yang
Chen, Weijie
Zhang, Xue
Bai, Lin
Tian, Sha
Tan, Subei
Xu, Chen
Song, Qi
Liu, Yalan
Zhong, Yunshi
Chen, Tianyin
Zhou, Pinghong
Zhao, Jian-Yuan
Hou, Yingyong
Ding, Chen
author_sort Li, Lingling
collection PubMed
description Esophageal squamous cell carcinoma (ESCC) is malignant while the carcinogenesis is still unclear. Here, we perform a comprehensive multi-omics analysis of 786 trace-tumor-samples from 154 ESCC patients, covering 9 histopathological stages and 3 phases. Proteogenomics elucidates cancer-driving waves in ESCC progression, and reveals the molecular characterization of alcohol drinking habit associated signatures. We discover chromosome 3q gain functions in the transmit from nontumor to intraepithelial neoplasia phases, and find TP53 mutation enhances DNA replication in intraepithelial neoplasia phase. The mutations of AKAP9 and MCAF1 upregulate glycolysis and Wnt signaling, respectively, in advanced-stage ESCC phase. Six major tracks related to different clinical features during ESCC progression are identified, which is validated by an independent cohort with another 256 samples. Hyperphosphorylated phosphoglycerate kinase 1 (PGK1, S203) is considered as a drug target in ESCC progression. This study provides insight into the understanding of ESCC molecular mechanism and the development of therapeutic targets.
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spelling pubmed-100398992023-03-27 Integrative proteogenomic characterization of early esophageal cancer Li, Lingling Jiang, Dongxian Zhang, Qiao Liu, Hui Xu, Fujiang Guo, Chunmei Qin, Zhaoyu Wang, Haixing Feng, Jinwen Liu, Yang Chen, Weijie Zhang, Xue Bai, Lin Tian, Sha Tan, Subei Xu, Chen Song, Qi Liu, Yalan Zhong, Yunshi Chen, Tianyin Zhou, Pinghong Zhao, Jian-Yuan Hou, Yingyong Ding, Chen Nat Commun Article Esophageal squamous cell carcinoma (ESCC) is malignant while the carcinogenesis is still unclear. Here, we perform a comprehensive multi-omics analysis of 786 trace-tumor-samples from 154 ESCC patients, covering 9 histopathological stages and 3 phases. Proteogenomics elucidates cancer-driving waves in ESCC progression, and reveals the molecular characterization of alcohol drinking habit associated signatures. We discover chromosome 3q gain functions in the transmit from nontumor to intraepithelial neoplasia phases, and find TP53 mutation enhances DNA replication in intraepithelial neoplasia phase. The mutations of AKAP9 and MCAF1 upregulate glycolysis and Wnt signaling, respectively, in advanced-stage ESCC phase. Six major tracks related to different clinical features during ESCC progression are identified, which is validated by an independent cohort with another 256 samples. Hyperphosphorylated phosphoglycerate kinase 1 (PGK1, S203) is considered as a drug target in ESCC progression. This study provides insight into the understanding of ESCC molecular mechanism and the development of therapeutic targets. Nature Publishing Group UK 2023-03-25 /pmc/articles/PMC10039899/ /pubmed/36966136 http://dx.doi.org/10.1038/s41467-023-37440-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Li, Lingling
Jiang, Dongxian
Zhang, Qiao
Liu, Hui
Xu, Fujiang
Guo, Chunmei
Qin, Zhaoyu
Wang, Haixing
Feng, Jinwen
Liu, Yang
Chen, Weijie
Zhang, Xue
Bai, Lin
Tian, Sha
Tan, Subei
Xu, Chen
Song, Qi
Liu, Yalan
Zhong, Yunshi
Chen, Tianyin
Zhou, Pinghong
Zhao, Jian-Yuan
Hou, Yingyong
Ding, Chen
Integrative proteogenomic characterization of early esophageal cancer
title Integrative proteogenomic characterization of early esophageal cancer
title_full Integrative proteogenomic characterization of early esophageal cancer
title_fullStr Integrative proteogenomic characterization of early esophageal cancer
title_full_unstemmed Integrative proteogenomic characterization of early esophageal cancer
title_short Integrative proteogenomic characterization of early esophageal cancer
title_sort integrative proteogenomic characterization of early esophageal cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039899/
https://www.ncbi.nlm.nih.gov/pubmed/36966136
http://dx.doi.org/10.1038/s41467-023-37440-w
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