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The Singapore Experience With Uncontrolled Gout: Unmet Needs in the Management of Patients
Gout is the most common type of inflammatory arthritis, and its impact on cardiovascular health and quality of life is often underestimated. The prevalence and incidence of gout are increasing globally. Further, ischemic heart disease (IHD) and chronic kidney disease (CKD) are prevalent in gout pati...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039979/ https://www.ncbi.nlm.nih.gov/pubmed/36987445 http://dx.doi.org/10.7759/cureus.36682 |
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author | Lee, Zheng Cong Santosa, Anindita Khor, Andrew Yu Keat Sriranganathan, Melonie K |
author_facet | Lee, Zheng Cong Santosa, Anindita Khor, Andrew Yu Keat Sriranganathan, Melonie K |
author_sort | Lee, Zheng Cong |
collection | PubMed |
description | Gout is the most common type of inflammatory arthritis, and its impact on cardiovascular health and quality of life is often underestimated. The prevalence and incidence of gout are increasing globally. Further, ischemic heart disease (IHD) and chronic kidney disease (CKD) are prevalent in gout patients. Some unmet needs for gout management include physicians' low initiation rate of urate-lowering therapy (ULT) and poor treatment adherence in patients with gout. There is also a lack of randomized controlled trials that establish safe doses of acute and long-term treatment for gout, particularly in patients with IHD and stage 4 CKD and above (including end-stage renal failure). Furthermore, there is also a lack of studies showing optimal serum uric acid (SUA) target and validated clinical outcome measures, including disease activity and remission criteria for gout tailored to treat-to-target approaches and the high cost of newer gout medications. The causal relationship between asymptomatic hyperuricemia or gout with comorbidities such as IHD and CKD has yet to be fully elucidated. There is a pressing need for collaborative international efforts to address the overall suboptimal management of gout. |
format | Online Article Text |
id | pubmed-10039979 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-100399792023-03-27 The Singapore Experience With Uncontrolled Gout: Unmet Needs in the Management of Patients Lee, Zheng Cong Santosa, Anindita Khor, Andrew Yu Keat Sriranganathan, Melonie K Cureus Internal Medicine Gout is the most common type of inflammatory arthritis, and its impact on cardiovascular health and quality of life is often underestimated. The prevalence and incidence of gout are increasing globally. Further, ischemic heart disease (IHD) and chronic kidney disease (CKD) are prevalent in gout patients. Some unmet needs for gout management include physicians' low initiation rate of urate-lowering therapy (ULT) and poor treatment adherence in patients with gout. There is also a lack of randomized controlled trials that establish safe doses of acute and long-term treatment for gout, particularly in patients with IHD and stage 4 CKD and above (including end-stage renal failure). Furthermore, there is also a lack of studies showing optimal serum uric acid (SUA) target and validated clinical outcome measures, including disease activity and remission criteria for gout tailored to treat-to-target approaches and the high cost of newer gout medications. The causal relationship between asymptomatic hyperuricemia or gout with comorbidities such as IHD and CKD has yet to be fully elucidated. There is a pressing need for collaborative international efforts to address the overall suboptimal management of gout. Cureus 2023-03-25 /pmc/articles/PMC10039979/ /pubmed/36987445 http://dx.doi.org/10.7759/cureus.36682 Text en Copyright © 2023, Lee et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Internal Medicine Lee, Zheng Cong Santosa, Anindita Khor, Andrew Yu Keat Sriranganathan, Melonie K The Singapore Experience With Uncontrolled Gout: Unmet Needs in the Management of Patients |
title | The Singapore Experience With Uncontrolled Gout: Unmet Needs in the Management of Patients |
title_full | The Singapore Experience With Uncontrolled Gout: Unmet Needs in the Management of Patients |
title_fullStr | The Singapore Experience With Uncontrolled Gout: Unmet Needs in the Management of Patients |
title_full_unstemmed | The Singapore Experience With Uncontrolled Gout: Unmet Needs in the Management of Patients |
title_short | The Singapore Experience With Uncontrolled Gout: Unmet Needs in the Management of Patients |
title_sort | singapore experience with uncontrolled gout: unmet needs in the management of patients |
topic | Internal Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039979/ https://www.ncbi.nlm.nih.gov/pubmed/36987445 http://dx.doi.org/10.7759/cureus.36682 |
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