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Adaptation of transgene mRNA translation boosts the anticancer efficacy of oncolytic HSV1

BACKGROUND: Transgenes deliver therapeutic payloads to improve oncolytic virus immunotherapy. Transgenes encoded within oncolytic viruses are designed to be highly transcribed, but protein synthesis is often negatively affected by viral infection, compromising the amount of therapeutic protein expre...

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Detalles Bibliográficos
Autores principales:	Hoang, Huy-Dung, Said, Aida, Vaidya, Nasana, Gilchrist, Victoria H, Malone, Kyle, Kabilan, Usha, Topshee, Serena, Xiang, Xiao, Yang, An-Dao, Olagnier, David, Mossman, Karen, Beug, Shawn T, Jafarnejad, Seyed Mehdi, Workenhe, Samuel T, Graber, Tyson E, Alain, Tommy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2023
Materias:	Oncolytic and Local Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040010/ https://www.ncbi.nlm.nih.gov/pubmed/36958764 http://dx.doi.org/10.1136/jitc-2022-006408

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