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Diagnosis and Treatment of Calcium Pyrophosphate Deposition (CPPD) Disease: A Review

Calcium Pyrophosphate Dihydrate (CPPD) crystal-related arthropathies are a common cause of acute and chronic arthritis caused by the deposition of calcium pyrophosphate crystals in joints and soft tissues, resulting in inflammation and joint damage. They present with a wide spectrum of clinical mani...

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Autores principales: Cowley, Sharon, McCarthy, Geraldine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040153/
https://www.ncbi.nlm.nih.gov/pubmed/36987530
http://dx.doi.org/10.2147/OARRR.S389664
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author Cowley, Sharon
McCarthy, Geraldine
author_facet Cowley, Sharon
McCarthy, Geraldine
author_sort Cowley, Sharon
collection PubMed
description Calcium Pyrophosphate Dihydrate (CPPD) crystal-related arthropathies are a common cause of acute and chronic arthritis caused by the deposition of calcium pyrophosphate crystals in joints and soft tissues, resulting in inflammation and joint damage. They present with a wide spectrum of clinical manifestations and often present challenges to diagnosis and management as they commonly affect older co-morbid patients. The challenges are compounded by a lack of a well-defined description of CPPD. However, an international expert-driven process is underway to develop CPPD classification criteria. Treatment is also problematic as unlike gout, there are no agents available that decrease the crystal burden. Treatment options have often been extrapolated from gout treatment pathways without having extensive trials or a solid evidence base. It is hoped the new CPPD classification guidelines will contribute to large multicentre studies, with well-defined patient cohorts, which will facilitate the production of high-quality evidence to guide the management of this condition. Here, we discuss the barriers and facilitators in diagnosing and treating CPPD-related arthropathy.
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spelling pubmed-100401532023-03-27 Diagnosis and Treatment of Calcium Pyrophosphate Deposition (CPPD) Disease: A Review Cowley, Sharon McCarthy, Geraldine Open Access Rheumatol Review Calcium Pyrophosphate Dihydrate (CPPD) crystal-related arthropathies are a common cause of acute and chronic arthritis caused by the deposition of calcium pyrophosphate crystals in joints and soft tissues, resulting in inflammation and joint damage. They present with a wide spectrum of clinical manifestations and often present challenges to diagnosis and management as they commonly affect older co-morbid patients. The challenges are compounded by a lack of a well-defined description of CPPD. However, an international expert-driven process is underway to develop CPPD classification criteria. Treatment is also problematic as unlike gout, there are no agents available that decrease the crystal burden. Treatment options have often been extrapolated from gout treatment pathways without having extensive trials or a solid evidence base. It is hoped the new CPPD classification guidelines will contribute to large multicentre studies, with well-defined patient cohorts, which will facilitate the production of high-quality evidence to guide the management of this condition. Here, we discuss the barriers and facilitators in diagnosing and treating CPPD-related arthropathy. Dove 2023-03-22 /pmc/articles/PMC10040153/ /pubmed/36987530 http://dx.doi.org/10.2147/OARRR.S389664 Text en © 2023 Cowley and McCarthy. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Cowley, Sharon
McCarthy, Geraldine
Diagnosis and Treatment of Calcium Pyrophosphate Deposition (CPPD) Disease: A Review
title Diagnosis and Treatment of Calcium Pyrophosphate Deposition (CPPD) Disease: A Review
title_full Diagnosis and Treatment of Calcium Pyrophosphate Deposition (CPPD) Disease: A Review
title_fullStr Diagnosis and Treatment of Calcium Pyrophosphate Deposition (CPPD) Disease: A Review
title_full_unstemmed Diagnosis and Treatment of Calcium Pyrophosphate Deposition (CPPD) Disease: A Review
title_short Diagnosis and Treatment of Calcium Pyrophosphate Deposition (CPPD) Disease: A Review
title_sort diagnosis and treatment of calcium pyrophosphate deposition (cppd) disease: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040153/
https://www.ncbi.nlm.nih.gov/pubmed/36987530
http://dx.doi.org/10.2147/OARRR.S389664
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