Cargando…
Genetic variants associated with longitudinal changes in brain structure across the lifespan
Human brain structure changes throughout our lives. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental, and neurodegenerative diseases. Here, we identified common genetic variants that affect rates of brain growth or atrophy, in the first genome-wid...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040206/ https://www.ncbi.nlm.nih.gov/pubmed/35383335 http://dx.doi.org/10.1038/s41593-022-01042-4 |
| _version_ | 1784912432312877056 |
|---|---|
| author | Brouwer, Rachel M. Klein, Marieke Grasby, Katrina L. Schnack, Hugo G. Jahanshad, Neda Teeuw, Jalmar Thomopoulos, Sophia I. Sprooten, Emma Franz, Carol E. Gogtay, Nitin Kremen, William S. Panizzon, Matthew S. Loohuis, Loes M. Olde Whelan, Christopher D. Aghajani, Moji Alloza, Clara Alnæs, Dag Artiges, Eric Ayesa-Arriola, Rosa Barker, Gareth J. Bastin, Mark E. Blok, Elisabet Bøen, Erlend Breukelaar, Isabella A. Bright, Joanna K. Buimer, Elizabeth E. L. Bülow, Robin Cannon, Dara M. Ciufolini, Simone Crossley, Nicolas A. Damatac, Christienne G. Dazzan, Paola de Mol, Casper L. de Zwarte, Sonja M. C. Desrivières, Sylvane Díaz-Caneja, Covadonga M. Doan, Nhat Trung Dohm, Katharina Fröhner, Juliane H. Goltermann, Janik Grigis, Antoine Grotegerd, Dominik Han, Laura K. M. Harris, Mathew A. Hartman, Catharina A. Heany, Sarah J. Heindel, Walter Heslenfeld, Dirk J. Hohmann, Sarah Ittermann, Bernd Jansen, Philip R. Janssen, Joost Jia, Tianye Jiang, Jiyang Jockwitz, Christiane Karali, Temmuz Keeser, Daniel Koevoets, Martijn G. J. C. Lenroot, Rhoshel K. Malchow, Berend Mandl, René C. W. Medel, Vicente Meinert, Susanne Morgan, Catherine A. Mühleisen, Thomas W. Nabulsi, Leila Opel, Nils de la Foz, Víctor Ortiz-García Overs, Bronwyn J. Martinot, Marie-Laure Paillère Redlich, Ronny Marques, Tiago Reis Repple, Jonathan Roberts, Gloria Roshchupkin, Gennady V. Setiaman, Nikita Shumskaya, Elena Stein, Frederike Sudre, Gustavo Takahashi, Shun Thalamuthu, Anbupalam Tordesillas-Gutiérrez, Diana van der Lugt, Aad van Haren, Neeltje E. M. Wardlaw, Joanna M. Wen, Wei Westeneng, Henk-Jan Wittfeld, Katharina Zhu, Alyssa H. Zugman, Andre Armstrong, Nicola J. Bonfiglio, Gaia Bralten, Janita Dalvie, Shareefa Davies, Gail Di Forti, Marta Ding, Linda Donohoe, Gary Forstner, Andreas J. Gonzalez-Peñas, Javier Guimaraes, Joao P. O. F. T. Homuth, Georg Hottenga, Jouke-Jan Knol, Maria J. Kwok, John B. J. Le Hellard, Stephanie Mather, Karen A. Milaneschi, Yuri Morris, Derek W. Nöthen, Markus M. Papiol, Sergi Rietschel, Marcella Santoro, Marcos L. Steen, Vidar M. Stein, Jason L. Streit, Fabian Tankard, Rick M. Teumer, Alexander van ’t Ent, Dennis van der Meer, Dennis van Eijk, Kristel R. Vassos, Evangelos Vázquez-Bourgon, Javier Witt, Stephanie H. Adams, Hieab H. H. Agartz, Ingrid Ames, David Amunts, Katrin Andreassen, Ole A. Arango, Celso Banaschewski, Tobias Baune, Bernhard T. Belangero, Sintia I. Bokde, Arun L. W. Boomsma, Dorret I. Bressan, Rodrigo A. Brodaty, Henry Buitelaar, Jan K. Cahn, Wiepke Caspers, Svenja Cichon, Sven Facorro, Benedicto Crespo Cox, Simon R. Dannlowski, Udo Elvsåshagen, Torbjørn Espeseth, Thomas Falkai, Peter G. Fisher, Simon E. Flor, Herta Fullerton, Janice M. Garavan, Hugh Gowland, Penny A. Grabe, Hans J. Hahn, Tim Heinz, Andreas Hillegers, Manon Hoare, Jacqueline Hoekstra, Pieter J. Ikram, Mohammad A. Jackowski, Andrea P. Jansen, Andreas Jönsson, Erik G. Kahn, Rene S. Kircher, Tilo Korgaonkar, Mayuresh S. Krug, Axel Lemaitre, Herve Malt, Ulrik F. Martinot, Jean-Luc McDonald, Colm Mitchell, Philip B. Muetzel, Ryan L. Murray, Robin M. Nees, Frauke Nenadić, Igor Oosterlaan, Jaap Ophoff, Roel A. Pan, Pedro M. Penninx, Brenda W. J. H. Poustka, Luise Sachdev, Perminder S. Salum, Giovanni A. Schofield, Peter R. Schumann, Gunter Shaw, Philip Sim, Kang Smolka, Michael N. Stein, Dan J. Trollor, Julian N. van den Berg, Leonard H. Veldink, Jan H. Walter, Henrik Westlye, Lars T. Whelan, Robert White, Tonya Wright, Margaret J. Medland, Sarah E. Franke, Barbara Thompson, Paul M. Hulshoff Pol, Hilleke E. |
| author_facet | Brouwer, Rachel M. Klein, Marieke Grasby, Katrina L. Schnack, Hugo G. Jahanshad, Neda Teeuw, Jalmar Thomopoulos, Sophia I. Sprooten, Emma Franz, Carol E. Gogtay, Nitin Kremen, William S. Panizzon, Matthew S. Loohuis, Loes M. Olde Whelan, Christopher D. Aghajani, Moji Alloza, Clara Alnæs, Dag Artiges, Eric Ayesa-Arriola, Rosa Barker, Gareth J. Bastin, Mark E. Blok, Elisabet Bøen, Erlend Breukelaar, Isabella A. Bright, Joanna K. Buimer, Elizabeth E. L. Bülow, Robin Cannon, Dara M. Ciufolini, Simone Crossley, Nicolas A. Damatac, Christienne G. Dazzan, Paola de Mol, Casper L. de Zwarte, Sonja M. C. Desrivières, Sylvane Díaz-Caneja, Covadonga M. Doan, Nhat Trung Dohm, Katharina Fröhner, Juliane H. Goltermann, Janik Grigis, Antoine Grotegerd, Dominik Han, Laura K. M. Harris, Mathew A. Hartman, Catharina A. Heany, Sarah J. Heindel, Walter Heslenfeld, Dirk J. Hohmann, Sarah Ittermann, Bernd Jansen, Philip R. Janssen, Joost Jia, Tianye Jiang, Jiyang Jockwitz, Christiane Karali, Temmuz Keeser, Daniel Koevoets, Martijn G. J. C. Lenroot, Rhoshel K. Malchow, Berend Mandl, René C. W. Medel, Vicente Meinert, Susanne Morgan, Catherine A. Mühleisen, Thomas W. Nabulsi, Leila Opel, Nils de la Foz, Víctor Ortiz-García Overs, Bronwyn J. Martinot, Marie-Laure Paillère Redlich, Ronny Marques, Tiago Reis Repple, Jonathan Roberts, Gloria Roshchupkin, Gennady V. Setiaman, Nikita Shumskaya, Elena Stein, Frederike Sudre, Gustavo Takahashi, Shun Thalamuthu, Anbupalam Tordesillas-Gutiérrez, Diana van der Lugt, Aad van Haren, Neeltje E. M. Wardlaw, Joanna M. Wen, Wei Westeneng, Henk-Jan Wittfeld, Katharina Zhu, Alyssa H. Zugman, Andre Armstrong, Nicola J. Bonfiglio, Gaia Bralten, Janita Dalvie, Shareefa Davies, Gail Di Forti, Marta Ding, Linda Donohoe, Gary Forstner, Andreas J. Gonzalez-Peñas, Javier Guimaraes, Joao P. O. F. T. Homuth, Georg Hottenga, Jouke-Jan Knol, Maria J. Kwok, John B. J. Le Hellard, Stephanie Mather, Karen A. Milaneschi, Yuri Morris, Derek W. Nöthen, Markus M. Papiol, Sergi Rietschel, Marcella Santoro, Marcos L. Steen, Vidar M. Stein, Jason L. Streit, Fabian Tankard, Rick M. Teumer, Alexander van ’t Ent, Dennis van der Meer, Dennis van Eijk, Kristel R. Vassos, Evangelos Vázquez-Bourgon, Javier Witt, Stephanie H. Adams, Hieab H. H. Agartz, Ingrid Ames, David Amunts, Katrin Andreassen, Ole A. Arango, Celso Banaschewski, Tobias Baune, Bernhard T. Belangero, Sintia I. Bokde, Arun L. W. Boomsma, Dorret I. Bressan, Rodrigo A. Brodaty, Henry Buitelaar, Jan K. Cahn, Wiepke Caspers, Svenja Cichon, Sven Facorro, Benedicto Crespo Cox, Simon R. Dannlowski, Udo Elvsåshagen, Torbjørn Espeseth, Thomas Falkai, Peter G. Fisher, Simon E. Flor, Herta Fullerton, Janice M. Garavan, Hugh Gowland, Penny A. Grabe, Hans J. Hahn, Tim Heinz, Andreas Hillegers, Manon Hoare, Jacqueline Hoekstra, Pieter J. Ikram, Mohammad A. Jackowski, Andrea P. Jansen, Andreas Jönsson, Erik G. Kahn, Rene S. Kircher, Tilo Korgaonkar, Mayuresh S. Krug, Axel Lemaitre, Herve Malt, Ulrik F. Martinot, Jean-Luc McDonald, Colm Mitchell, Philip B. Muetzel, Ryan L. Murray, Robin M. Nees, Frauke Nenadić, Igor Oosterlaan, Jaap Ophoff, Roel A. Pan, Pedro M. Penninx, Brenda W. J. H. Poustka, Luise Sachdev, Perminder S. Salum, Giovanni A. Schofield, Peter R. Schumann, Gunter Shaw, Philip Sim, Kang Smolka, Michael N. Stein, Dan J. Trollor, Julian N. van den Berg, Leonard H. Veldink, Jan H. Walter, Henrik Westlye, Lars T. Whelan, Robert White, Tonya Wright, Margaret J. Medland, Sarah E. Franke, Barbara Thompson, Paul M. Hulshoff Pol, Hilleke E. |
| author_sort | Brouwer, Rachel M. |
| collection | PubMed |
| description | Human brain structure changes throughout our lives. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental, and neurodegenerative diseases. Here, we identified common genetic variants that affect rates of brain growth or atrophy, in the first genome-wide association meta-analysis of changes in brain morphology across the lifespan. Longitudinal MRI data from 15,640 individuals were used to compute rates of change for 15 brain structures. The most robustly identified genes GPR139, DACH1 and APOE are associated with metabolic processes. We demonstrate global genetic overlap with depression, schizophrenia, cognitive functioning, insomnia, height, body mass index and smoking. Gene-set findings implicate both early brain development and neurodegenerative processes in the rates of brain changes. Identifying variants involved in structural brain changes may help to determine biological pathways underlying optimal and dysfunctional brain development and ageing. |
| format | Online Article Text |
| id | pubmed-10040206 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-100402062023-03-26 Genetic variants associated with longitudinal changes in brain structure across the lifespan Brouwer, Rachel M. Klein, Marieke Grasby, Katrina L. Schnack, Hugo G. Jahanshad, Neda Teeuw, Jalmar Thomopoulos, Sophia I. Sprooten, Emma Franz, Carol E. Gogtay, Nitin Kremen, William S. Panizzon, Matthew S. Loohuis, Loes M. Olde Whelan, Christopher D. Aghajani, Moji Alloza, Clara Alnæs, Dag Artiges, Eric Ayesa-Arriola, Rosa Barker, Gareth J. Bastin, Mark E. Blok, Elisabet Bøen, Erlend Breukelaar, Isabella A. Bright, Joanna K. Buimer, Elizabeth E. L. Bülow, Robin Cannon, Dara M. Ciufolini, Simone Crossley, Nicolas A. Damatac, Christienne G. Dazzan, Paola de Mol, Casper L. de Zwarte, Sonja M. C. Desrivières, Sylvane Díaz-Caneja, Covadonga M. Doan, Nhat Trung Dohm, Katharina Fröhner, Juliane H. Goltermann, Janik Grigis, Antoine Grotegerd, Dominik Han, Laura K. M. Harris, Mathew A. Hartman, Catharina A. Heany, Sarah J. Heindel, Walter Heslenfeld, Dirk J. Hohmann, Sarah Ittermann, Bernd Jansen, Philip R. Janssen, Joost Jia, Tianye Jiang, Jiyang Jockwitz, Christiane Karali, Temmuz Keeser, Daniel Koevoets, Martijn G. J. C. Lenroot, Rhoshel K. Malchow, Berend Mandl, René C. W. Medel, Vicente Meinert, Susanne Morgan, Catherine A. Mühleisen, Thomas W. Nabulsi, Leila Opel, Nils de la Foz, Víctor Ortiz-García Overs, Bronwyn J. Martinot, Marie-Laure Paillère Redlich, Ronny Marques, Tiago Reis Repple, Jonathan Roberts, Gloria Roshchupkin, Gennady V. Setiaman, Nikita Shumskaya, Elena Stein, Frederike Sudre, Gustavo Takahashi, Shun Thalamuthu, Anbupalam Tordesillas-Gutiérrez, Diana van der Lugt, Aad van Haren, Neeltje E. M. Wardlaw, Joanna M. Wen, Wei Westeneng, Henk-Jan Wittfeld, Katharina Zhu, Alyssa H. Zugman, Andre Armstrong, Nicola J. Bonfiglio, Gaia Bralten, Janita Dalvie, Shareefa Davies, Gail Di Forti, Marta Ding, Linda Donohoe, Gary Forstner, Andreas J. Gonzalez-Peñas, Javier Guimaraes, Joao P. O. F. T. Homuth, Georg Hottenga, Jouke-Jan Knol, Maria J. Kwok, John B. J. Le Hellard, Stephanie Mather, Karen A. Milaneschi, Yuri Morris, Derek W. Nöthen, Markus M. Papiol, Sergi Rietschel, Marcella Santoro, Marcos L. Steen, Vidar M. Stein, Jason L. Streit, Fabian Tankard, Rick M. Teumer, Alexander van ’t Ent, Dennis van der Meer, Dennis van Eijk, Kristel R. Vassos, Evangelos Vázquez-Bourgon, Javier Witt, Stephanie H. Adams, Hieab H. H. Agartz, Ingrid Ames, David Amunts, Katrin Andreassen, Ole A. Arango, Celso Banaschewski, Tobias Baune, Bernhard T. Belangero, Sintia I. Bokde, Arun L. W. Boomsma, Dorret I. Bressan, Rodrigo A. Brodaty, Henry Buitelaar, Jan K. Cahn, Wiepke Caspers, Svenja Cichon, Sven Facorro, Benedicto Crespo Cox, Simon R. Dannlowski, Udo Elvsåshagen, Torbjørn Espeseth, Thomas Falkai, Peter G. Fisher, Simon E. Flor, Herta Fullerton, Janice M. Garavan, Hugh Gowland, Penny A. Grabe, Hans J. Hahn, Tim Heinz, Andreas Hillegers, Manon Hoare, Jacqueline Hoekstra, Pieter J. Ikram, Mohammad A. Jackowski, Andrea P. Jansen, Andreas Jönsson, Erik G. Kahn, Rene S. Kircher, Tilo Korgaonkar, Mayuresh S. Krug, Axel Lemaitre, Herve Malt, Ulrik F. Martinot, Jean-Luc McDonald, Colm Mitchell, Philip B. Muetzel, Ryan L. Murray, Robin M. Nees, Frauke Nenadić, Igor Oosterlaan, Jaap Ophoff, Roel A. Pan, Pedro M. Penninx, Brenda W. J. H. Poustka, Luise Sachdev, Perminder S. Salum, Giovanni A. Schofield, Peter R. Schumann, Gunter Shaw, Philip Sim, Kang Smolka, Michael N. Stein, Dan J. Trollor, Julian N. van den Berg, Leonard H. Veldink, Jan H. Walter, Henrik Westlye, Lars T. Whelan, Robert White, Tonya Wright, Margaret J. Medland, Sarah E. Franke, Barbara Thompson, Paul M. Hulshoff Pol, Hilleke E. Nat Neurosci Article Human brain structure changes throughout our lives. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental, and neurodegenerative diseases. Here, we identified common genetic variants that affect rates of brain growth or atrophy, in the first genome-wide association meta-analysis of changes in brain morphology across the lifespan. Longitudinal MRI data from 15,640 individuals were used to compute rates of change for 15 brain structures. The most robustly identified genes GPR139, DACH1 and APOE are associated with metabolic processes. We demonstrate global genetic overlap with depression, schizophrenia, cognitive functioning, insomnia, height, body mass index and smoking. Gene-set findings implicate both early brain development and neurodegenerative processes in the rates of brain changes. Identifying variants involved in structural brain changes may help to determine biological pathways underlying optimal and dysfunctional brain development and ageing. 2022-04 2022-04-05 /pmc/articles/PMC10040206/ /pubmed/35383335 http://dx.doi.org/10.1038/s41593-022-01042-4 Text en http://www.nature.com/authors/editorial_policies/license.html#termsUsers may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Brouwer, Rachel M. Klein, Marieke Grasby, Katrina L. Schnack, Hugo G. Jahanshad, Neda Teeuw, Jalmar Thomopoulos, Sophia I. Sprooten, Emma Franz, Carol E. Gogtay, Nitin Kremen, William S. Panizzon, Matthew S. Loohuis, Loes M. Olde Whelan, Christopher D. Aghajani, Moji Alloza, Clara Alnæs, Dag Artiges, Eric Ayesa-Arriola, Rosa Barker, Gareth J. Bastin, Mark E. Blok, Elisabet Bøen, Erlend Breukelaar, Isabella A. Bright, Joanna K. Buimer, Elizabeth E. L. Bülow, Robin Cannon, Dara M. Ciufolini, Simone Crossley, Nicolas A. Damatac, Christienne G. Dazzan, Paola de Mol, Casper L. de Zwarte, Sonja M. C. Desrivières, Sylvane Díaz-Caneja, Covadonga M. Doan, Nhat Trung Dohm, Katharina Fröhner, Juliane H. Goltermann, Janik Grigis, Antoine Grotegerd, Dominik Han, Laura K. M. Harris, Mathew A. Hartman, Catharina A. Heany, Sarah J. Heindel, Walter Heslenfeld, Dirk J. Hohmann, Sarah Ittermann, Bernd Jansen, Philip R. Janssen, Joost Jia, Tianye Jiang, Jiyang Jockwitz, Christiane Karali, Temmuz Keeser, Daniel Koevoets, Martijn G. J. C. Lenroot, Rhoshel K. Malchow, Berend Mandl, René C. W. Medel, Vicente Meinert, Susanne Morgan, Catherine A. Mühleisen, Thomas W. Nabulsi, Leila Opel, Nils de la Foz, Víctor Ortiz-García Overs, Bronwyn J. Martinot, Marie-Laure Paillère Redlich, Ronny Marques, Tiago Reis Repple, Jonathan Roberts, Gloria Roshchupkin, Gennady V. Setiaman, Nikita Shumskaya, Elena Stein, Frederike Sudre, Gustavo Takahashi, Shun Thalamuthu, Anbupalam Tordesillas-Gutiérrez, Diana van der Lugt, Aad van Haren, Neeltje E. M. Wardlaw, Joanna M. Wen, Wei Westeneng, Henk-Jan Wittfeld, Katharina Zhu, Alyssa H. Zugman, Andre Armstrong, Nicola J. Bonfiglio, Gaia Bralten, Janita Dalvie, Shareefa Davies, Gail Di Forti, Marta Ding, Linda Donohoe, Gary Forstner, Andreas J. Gonzalez-Peñas, Javier Guimaraes, Joao P. O. F. T. Homuth, Georg Hottenga, Jouke-Jan Knol, Maria J. Kwok, John B. J. Le Hellard, Stephanie Mather, Karen A. Milaneschi, Yuri Morris, Derek W. Nöthen, Markus M. Papiol, Sergi Rietschel, Marcella Santoro, Marcos L. Steen, Vidar M. Stein, Jason L. Streit, Fabian Tankard, Rick M. Teumer, Alexander van ’t Ent, Dennis van der Meer, Dennis van Eijk, Kristel R. Vassos, Evangelos Vázquez-Bourgon, Javier Witt, Stephanie H. Adams, Hieab H. H. Agartz, Ingrid Ames, David Amunts, Katrin Andreassen, Ole A. Arango, Celso Banaschewski, Tobias Baune, Bernhard T. Belangero, Sintia I. Bokde, Arun L. W. Boomsma, Dorret I. Bressan, Rodrigo A. Brodaty, Henry Buitelaar, Jan K. Cahn, Wiepke Caspers, Svenja Cichon, Sven Facorro, Benedicto Crespo Cox, Simon R. Dannlowski, Udo Elvsåshagen, Torbjørn Espeseth, Thomas Falkai, Peter G. Fisher, Simon E. Flor, Herta Fullerton, Janice M. Garavan, Hugh Gowland, Penny A. Grabe, Hans J. Hahn, Tim Heinz, Andreas Hillegers, Manon Hoare, Jacqueline Hoekstra, Pieter J. Ikram, Mohammad A. Jackowski, Andrea P. Jansen, Andreas Jönsson, Erik G. Kahn, Rene S. Kircher, Tilo Korgaonkar, Mayuresh S. Krug, Axel Lemaitre, Herve Malt, Ulrik F. Martinot, Jean-Luc McDonald, Colm Mitchell, Philip B. Muetzel, Ryan L. Murray, Robin M. Nees, Frauke Nenadić, Igor Oosterlaan, Jaap Ophoff, Roel A. Pan, Pedro M. Penninx, Brenda W. J. H. Poustka, Luise Sachdev, Perminder S. Salum, Giovanni A. Schofield, Peter R. Schumann, Gunter Shaw, Philip Sim, Kang Smolka, Michael N. Stein, Dan J. Trollor, Julian N. van den Berg, Leonard H. Veldink, Jan H. Walter, Henrik Westlye, Lars T. Whelan, Robert White, Tonya Wright, Margaret J. Medland, Sarah E. Franke, Barbara Thompson, Paul M. Hulshoff Pol, Hilleke E. Genetic variants associated with longitudinal changes in brain structure across the lifespan |
| title | Genetic variants associated with longitudinal changes in brain structure across the lifespan |
| title_full | Genetic variants associated with longitudinal changes in brain structure across the lifespan |
| title_fullStr | Genetic variants associated with longitudinal changes in brain structure across the lifespan |
| title_full_unstemmed | Genetic variants associated with longitudinal changes in brain structure across the lifespan |
| title_short | Genetic variants associated with longitudinal changes in brain structure across the lifespan |
| title_sort | genetic variants associated with longitudinal changes in brain structure across the lifespan |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040206/ https://www.ncbi.nlm.nih.gov/pubmed/35383335 http://dx.doi.org/10.1038/s41593-022-01042-4 |
| work_keys_str_mv | AT brouwerrachelm geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT kleinmarieke geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT grasbykatrinal geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT schnackhugog geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT jahanshadneda geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT teeuwjalmar geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT thomopoulossophiai geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT sprootenemma geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT franzcarole geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT gogtaynitin geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT kremenwilliams geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT panizzonmatthews geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT loohuisloesmolde geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT whelanchristopherd geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT aghajanimoji geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT allozaclara geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT alnæsdag geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT artigeseric geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT ayesaarriolarosa geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT barkergarethj geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT bastinmarke geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT blokelisabet geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT bøenerlend geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT breukelaarisabellaa geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT brightjoannak geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT buimerelizabethel geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT bulowrobin geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT cannondaram geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT ciufolinisimone geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT crossleynicolasa geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT damatacchristienneg geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT dazzanpaola geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT demolcasperl geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT dezwartesonjamc geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT desrivieressylvane geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT diazcanejacovadongam geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT doannhattrung geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT dohmkatharina geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT frohnerjulianeh geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT goltermannjanik geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT grigisantoine geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT grotegerddominik geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT hanlaurakm geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT harrismathewa geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT hartmancatharinaa geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT heanysarahj geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT heindelwalter geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT heslenfelddirkj geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT hohmannsarah geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT ittermannbernd geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT jansenphilipr geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT janssenjoost geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT jiatianye geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT jiangjiyang geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT jockwitzchristiane geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT karalitemmuz geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT keeserdaniel geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT koevoetsmartijngjc geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT lenrootrhoshelk geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT malchowberend geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT mandlrenecw geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT medelvicente geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT meinertsusanne geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT morgancatherinea geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT muhleisenthomasw geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT nabulsileila geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT opelnils geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT delafozvictorortizgarcia geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT oversbronwynj geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT martinotmarielaurepaillere geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT redlichronny geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT marquestiagoreis geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT repplejonathan geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT robertsgloria geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT roshchupkingennadyv geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT setiamannikita geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT shumskayaelena geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT steinfrederike geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT sudregustavo geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT takahashishun geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT thalamuthuanbupalam geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT tordesillasgutierrezdiana geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT vanderlugtaad geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT vanharenneeltjeem geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT wardlawjoannam geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT wenwei geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT westenenghenkjan geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT wittfeldkatharina geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT zhualyssah geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT zugmanandre geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT armstrongnicolaj geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT bonfigliogaia geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT braltenjanita geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT dalvieshareefa geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT daviesgail geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT difortimarta geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT dinglinda geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT donohoegary geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT forstnerandreasj geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT gonzalezpenasjavier geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT guimaraesjoaopoft geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT homuthgeorg geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT hottengajoukejan geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT knolmariaj geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT kwokjohnbj geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT lehellardstephanie geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT matherkarena geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT milaneschiyuri geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT morrisderekw geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT nothenmarkusm geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT papiolsergi geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT rietschelmarcella geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT santoromarcosl geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT steenvidarm geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT steinjasonl geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT streitfabian geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT tankardrickm geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT teumeralexander geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT vantentdennis geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT vandermeerdennis geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT vaneijkkristelr geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT vassosevangelos geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT vazquezbourgonjavier geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT wittstephanieh geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT adamshieabhh geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT agartzingrid geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT amesdavid geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT amuntskatrin geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT andreassenolea geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT arangocelso geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT banaschewskitobias geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT baunebernhardt geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT belangerosintiai geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT bokdearunlw geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT boomsmadorreti geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT bressanrodrigoa geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT brodatyhenry geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT buitelaarjank geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT cahnwiepke geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT casperssvenja geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT cichonsven geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT facorrobenedictocrespo geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT coxsimonr geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT dannlowskiudo geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT elvsashagentorbjørn geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT espeseththomas geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT falkaipeterg geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT fishersimone geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT florherta geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT fullertonjanicem geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT garavanhugh geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT gowlandpennya geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT grabehansj geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT hahntim geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT heinzandreas geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT hillegersmanon geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT hoarejacqueline geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT hoekstrapieterj geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT ikrammohammada geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT jackowskiandreap geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT jansenandreas geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT jonssonerikg geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT kahnrenes geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT kirchertilo geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT korgaonkarmayureshs geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT krugaxel geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT lemaitreherve geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT maltulrikf geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT martinotjeanluc geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT mcdonaldcolm geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT mitchellphilipb geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT muetzelryanl geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT murrayrobinm geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT neesfrauke geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT nenadicigor geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT oosterlaanjaap geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT ophoffroela geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT panpedrom geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT penninxbrendawjh geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT poustkaluise geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT sachdevperminders geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT salumgiovannia geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT schofieldpeterr geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT schumanngunter geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT shawphilip geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT simkang geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT smolkamichaeln geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT steindanj geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT trollorjuliann geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT vandenbergleonardh geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT veldinkjanh geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT walterhenrik geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT westlyelarst geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT whelanrobert geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT whitetonya geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT wrightmargaretj geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT medlandsarahe geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT frankebarbara geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT thompsonpaulm geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan AT hulshoffpolhillekee geneticvariantsassociatedwithlongitudinalchangesinbrainstructureacrossthelifespan |