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The Associations between Bone Mineral Density and Oxidative Stress Biomarkers in Postmenopausal Women

BACKGROUND: Oxidative stress plays an essential role in bone health among postmenopausal women. This study aimed to compare the oxidative stress biomarkers among postmenopausal women aged 50–65 years with normal bone mineral density, osteopenia, and osteoporosis. METHODS: In this observational study...

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Autores principales: Malekian, Sanaz, Mirghafourvand, Mojgan, Najafipour, Farzad, Ostadrahimi, Alireza, Ghassab-Abdollahi, Nafiseh, Farshbaf-Khalili, Azizeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Academy of Family Medicine 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040269/
https://www.ncbi.nlm.nih.gov/pubmed/36966739
http://dx.doi.org/10.4082/kjfm.22.0022
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author Malekian, Sanaz
Mirghafourvand, Mojgan
Najafipour, Farzad
Ostadrahimi, Alireza
Ghassab-Abdollahi, Nafiseh
Farshbaf-Khalili, Azizeh
author_facet Malekian, Sanaz
Mirghafourvand, Mojgan
Najafipour, Farzad
Ostadrahimi, Alireza
Ghassab-Abdollahi, Nafiseh
Farshbaf-Khalili, Azizeh
author_sort Malekian, Sanaz
collection PubMed
description BACKGROUND: Oxidative stress plays an essential role in bone health among postmenopausal women. This study aimed to compare the oxidative stress biomarkers among postmenopausal women aged 50–65 years with normal bone mineral density, osteopenia, and osteoporosis. METHODS: In this observational study, 120 women with normal bone mineral density, 82 with osteopenia, and 86 with osteoporosis were selected based on the densitometry data obtained from the dual-energy X-ray absorptiometry method. The serum total antioxidant capacity (TAC), superoxide dismutase (SOD) activity, and malondialdehyde (MDA) levels were measured using biochemical methods. A binary logistic regression model adjusted for confounders was used to estimate the risk of osteopenia and osteoporosis. The P-value of <0.05 was considered statistically significant. RESULTS: There were significant differences between the three groups in age, menopausal age, body mass index, and education (P<0.05). According to the binary logistic regression model, higher SOD activity and serum TAC levels were associated with a lower risk of osteoporosis (adjusted odds ratio [aOR], 0.991; 95% confidence intervals [CI], 0.986 to 0.996; and aOR, 0.373; 95% CI, 0.141 to 0.986, respectively). MDA was a significant risk factor for osteopenia in postmenopausal women (aOR, 1.702; 95% CI, 1.125 to 2.576). CONCLUSION: Higher SOD activity and serum TAC levels in the studied postmenopausal women were associated with a significantly lower risk of osteoporosis. Moreover, the risk of osteopenia increased significantly with higher serum MDA levels.
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spelling pubmed-100402692023-03-27 The Associations between Bone Mineral Density and Oxidative Stress Biomarkers in Postmenopausal Women Malekian, Sanaz Mirghafourvand, Mojgan Najafipour, Farzad Ostadrahimi, Alireza Ghassab-Abdollahi, Nafiseh Farshbaf-Khalili, Azizeh Korean J Fam Med Original Article BACKGROUND: Oxidative stress plays an essential role in bone health among postmenopausal women. This study aimed to compare the oxidative stress biomarkers among postmenopausal women aged 50–65 years with normal bone mineral density, osteopenia, and osteoporosis. METHODS: In this observational study, 120 women with normal bone mineral density, 82 with osteopenia, and 86 with osteoporosis were selected based on the densitometry data obtained from the dual-energy X-ray absorptiometry method. The serum total antioxidant capacity (TAC), superoxide dismutase (SOD) activity, and malondialdehyde (MDA) levels were measured using biochemical methods. A binary logistic regression model adjusted for confounders was used to estimate the risk of osteopenia and osteoporosis. The P-value of <0.05 was considered statistically significant. RESULTS: There were significant differences between the three groups in age, menopausal age, body mass index, and education (P<0.05). According to the binary logistic regression model, higher SOD activity and serum TAC levels were associated with a lower risk of osteoporosis (adjusted odds ratio [aOR], 0.991; 95% confidence intervals [CI], 0.986 to 0.996; and aOR, 0.373; 95% CI, 0.141 to 0.986, respectively). MDA was a significant risk factor for osteopenia in postmenopausal women (aOR, 1.702; 95% CI, 1.125 to 2.576). CONCLUSION: Higher SOD activity and serum TAC levels in the studied postmenopausal women were associated with a significantly lower risk of osteoporosis. Moreover, the risk of osteopenia increased significantly with higher serum MDA levels. Korean Academy of Family Medicine 2023-03 2023-03-20 /pmc/articles/PMC10040269/ /pubmed/36966739 http://dx.doi.org/10.4082/kjfm.22.0022 Text en Copyright © 2023 The Korean Academy of Family Medicine https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Malekian, Sanaz
Mirghafourvand, Mojgan
Najafipour, Farzad
Ostadrahimi, Alireza
Ghassab-Abdollahi, Nafiseh
Farshbaf-Khalili, Azizeh
The Associations between Bone Mineral Density and Oxidative Stress Biomarkers in Postmenopausal Women
title The Associations between Bone Mineral Density and Oxidative Stress Biomarkers in Postmenopausal Women
title_full The Associations between Bone Mineral Density and Oxidative Stress Biomarkers in Postmenopausal Women
title_fullStr The Associations between Bone Mineral Density and Oxidative Stress Biomarkers in Postmenopausal Women
title_full_unstemmed The Associations between Bone Mineral Density and Oxidative Stress Biomarkers in Postmenopausal Women
title_short The Associations between Bone Mineral Density and Oxidative Stress Biomarkers in Postmenopausal Women
title_sort associations between bone mineral density and oxidative stress biomarkers in postmenopausal women
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040269/
https://www.ncbi.nlm.nih.gov/pubmed/36966739
http://dx.doi.org/10.4082/kjfm.22.0022
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