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Data-driven subgroups of prediabetes and the associations with outcomes in Chinese adults
Prediabetes and its pathophysiology remain important issues. We aimed to examine the cluster characteristics of prediabetes and explore their associations with developing diabetes and its complications based on 12 variables representing body fat, glycemic measures, pancreatic β cell function, insuli...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040373/ https://www.ncbi.nlm.nih.gov/pubmed/36863337 http://dx.doi.org/10.1016/j.xcrm.2023.100958 |
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| author | Zheng, Ruizhi Xu, Yu Li, Mian Gao, Zhengnan Wang, Guixia Hou, Xinguo Chen, Li Huo, Yanan Qin, Guijun Yan, Li Wan, Qin Zeng, Tianshu Chen, Lulu Shi, Lixin Hu, Ruying Tang, Xulei Su, Qing Yu, Xuefeng Qin, Yingfen Chen, Gang Gu, Xuejiang Shen, Feixia Luo, Zuojie Chen, Yuhong Zhang, Yinfei Liu, Chao Wang, Youmin Wu, Shengli Yang, Tao Li, Qiang Mu, Yiming Zhao, Jiajun Hu, Chunyan Jia, Xiaojing Xu, Min Wang, Tiange Zhao, Zhiyun Wang, Shuangyuan Lin, Hong Ning, Guang Wang, Weiqing Lu, Jieli Bi, Yufang |
| author_facet | Zheng, Ruizhi Xu, Yu Li, Mian Gao, Zhengnan Wang, Guixia Hou, Xinguo Chen, Li Huo, Yanan Qin, Guijun Yan, Li Wan, Qin Zeng, Tianshu Chen, Lulu Shi, Lixin Hu, Ruying Tang, Xulei Su, Qing Yu, Xuefeng Qin, Yingfen Chen, Gang Gu, Xuejiang Shen, Feixia Luo, Zuojie Chen, Yuhong Zhang, Yinfei Liu, Chao Wang, Youmin Wu, Shengli Yang, Tao Li, Qiang Mu, Yiming Zhao, Jiajun Hu, Chunyan Jia, Xiaojing Xu, Min Wang, Tiange Zhao, Zhiyun Wang, Shuangyuan Lin, Hong Ning, Guang Wang, Weiqing Lu, Jieli Bi, Yufang |
| author_sort | Zheng, Ruizhi |
| collection | PubMed |
| description | Prediabetes and its pathophysiology remain important issues. We aimed to examine the cluster characteristics of prediabetes and explore their associations with developing diabetes and its complications based on 12 variables representing body fat, glycemic measures, pancreatic β cell function, insulin resistance, blood lipids, and liver enzymes. A total of 55,777 individuals with prediabetes from the China Cardiometabolic Disease and Cancer Cohort (4C) were classified at baseline into six clusters. During a median of 3.1 years of follow-up, significant differences in the risks of diabetes and its complications between clusters were observed. The odds ratios of diabetes stepwisely increase from cluster 1 to cluster 6. Clusters 1, 4, and 6 have increased chronic kidney diseases risks, while the prediabetes in cluster 4, characterized by obesity and insulin resistance, confers higher risks of cardiovascular diseases compared with others. This subcategorization has potential value in developing more precise strategies for targeted prediabetes prevention and treatment. |
| format | Online Article Text |
| id | pubmed-10040373 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-100403732023-03-28 Data-driven subgroups of prediabetes and the associations with outcomes in Chinese adults Zheng, Ruizhi Xu, Yu Li, Mian Gao, Zhengnan Wang, Guixia Hou, Xinguo Chen, Li Huo, Yanan Qin, Guijun Yan, Li Wan, Qin Zeng, Tianshu Chen, Lulu Shi, Lixin Hu, Ruying Tang, Xulei Su, Qing Yu, Xuefeng Qin, Yingfen Chen, Gang Gu, Xuejiang Shen, Feixia Luo, Zuojie Chen, Yuhong Zhang, Yinfei Liu, Chao Wang, Youmin Wu, Shengli Yang, Tao Li, Qiang Mu, Yiming Zhao, Jiajun Hu, Chunyan Jia, Xiaojing Xu, Min Wang, Tiange Zhao, Zhiyun Wang, Shuangyuan Lin, Hong Ning, Guang Wang, Weiqing Lu, Jieli Bi, Yufang Cell Rep Med Article Prediabetes and its pathophysiology remain important issues. We aimed to examine the cluster characteristics of prediabetes and explore their associations with developing diabetes and its complications based on 12 variables representing body fat, glycemic measures, pancreatic β cell function, insulin resistance, blood lipids, and liver enzymes. A total of 55,777 individuals with prediabetes from the China Cardiometabolic Disease and Cancer Cohort (4C) were classified at baseline into six clusters. During a median of 3.1 years of follow-up, significant differences in the risks of diabetes and its complications between clusters were observed. The odds ratios of diabetes stepwisely increase from cluster 1 to cluster 6. Clusters 1, 4, and 6 have increased chronic kidney diseases risks, while the prediabetes in cluster 4, characterized by obesity and insulin resistance, confers higher risks of cardiovascular diseases compared with others. This subcategorization has potential value in developing more precise strategies for targeted prediabetes prevention and treatment. Elsevier 2023-03-01 /pmc/articles/PMC10040373/ /pubmed/36863337 http://dx.doi.org/10.1016/j.xcrm.2023.100958 Text en © 2023. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Article Zheng, Ruizhi Xu, Yu Li, Mian Gao, Zhengnan Wang, Guixia Hou, Xinguo Chen, Li Huo, Yanan Qin, Guijun Yan, Li Wan, Qin Zeng, Tianshu Chen, Lulu Shi, Lixin Hu, Ruying Tang, Xulei Su, Qing Yu, Xuefeng Qin, Yingfen Chen, Gang Gu, Xuejiang Shen, Feixia Luo, Zuojie Chen, Yuhong Zhang, Yinfei Liu, Chao Wang, Youmin Wu, Shengli Yang, Tao Li, Qiang Mu, Yiming Zhao, Jiajun Hu, Chunyan Jia, Xiaojing Xu, Min Wang, Tiange Zhao, Zhiyun Wang, Shuangyuan Lin, Hong Ning, Guang Wang, Weiqing Lu, Jieli Bi, Yufang Data-driven subgroups of prediabetes and the associations with outcomes in Chinese adults |
| title | Data-driven subgroups of prediabetes and the associations with outcomes in Chinese adults |
| title_full | Data-driven subgroups of prediabetes and the associations with outcomes in Chinese adults |
| title_fullStr | Data-driven subgroups of prediabetes and the associations with outcomes in Chinese adults |
| title_full_unstemmed | Data-driven subgroups of prediabetes and the associations with outcomes in Chinese adults |
| title_short | Data-driven subgroups of prediabetes and the associations with outcomes in Chinese adults |
| title_sort | data-driven subgroups of prediabetes and the associations with outcomes in chinese adults |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040373/ https://www.ncbi.nlm.nih.gov/pubmed/36863337 http://dx.doi.org/10.1016/j.xcrm.2023.100958 |
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