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Going nuclear: Molecular adaptations to exercise mediated by myonuclei
Muscle fibers are multinucleated, and muscle fiber nuclei (myonuclei) are believed to be post-mitotic and are typically situated near the periphery of the myofiber. Due to the unique organization of muscle fibers and their nuclei, the cellular and molecular mechanisms regulating myofiber homeostasis...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Chengdu Sport University
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040379/ https://www.ncbi.nlm.nih.gov/pubmed/36994170 http://dx.doi.org/10.1016/j.smhs.2022.11.005 |
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author | Koopmans, Pieter J. Zwetsloot, Kevin A. Murach, Kevin A. |
author_facet | Koopmans, Pieter J. Zwetsloot, Kevin A. Murach, Kevin A. |
author_sort | Koopmans, Pieter J. |
collection | PubMed |
description | Muscle fibers are multinucleated, and muscle fiber nuclei (myonuclei) are believed to be post-mitotic and are typically situated near the periphery of the myofiber. Due to the unique organization of muscle fibers and their nuclei, the cellular and molecular mechanisms regulating myofiber homeostasis in unstressed and stressed conditions (e.g., exercise) are unique. A key role myonuclei play in regulating muscle during exercise is gene transcription. Only recently have investigators had the capability to identify molecular changes at high resolution exclusively in myonuclei in response to perturbations in vivo. The purpose of this review is to describe how myonuclei modulate their transcriptome, epigenetic status, mobility and shape, and microRNA expression in response to exercise in vivo. Given the relative paucity of high-fidelity information on myonucleus-specific contributions to exercise adaptation, we identify specific gaps in knowledge and provide perspectives on future directions of research. |
format | Online Article Text |
id | pubmed-10040379 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Chengdu Sport University |
record_format | MEDLINE/PubMed |
spelling | pubmed-100403792023-03-28 Going nuclear: Molecular adaptations to exercise mediated by myonuclei Koopmans, Pieter J. Zwetsloot, Kevin A. Murach, Kevin A. Sports Med Health Sci Review Muscle fibers are multinucleated, and muscle fiber nuclei (myonuclei) are believed to be post-mitotic and are typically situated near the periphery of the myofiber. Due to the unique organization of muscle fibers and their nuclei, the cellular and molecular mechanisms regulating myofiber homeostasis in unstressed and stressed conditions (e.g., exercise) are unique. A key role myonuclei play in regulating muscle during exercise is gene transcription. Only recently have investigators had the capability to identify molecular changes at high resolution exclusively in myonuclei in response to perturbations in vivo. The purpose of this review is to describe how myonuclei modulate their transcriptome, epigenetic status, mobility and shape, and microRNA expression in response to exercise in vivo. Given the relative paucity of high-fidelity information on myonucleus-specific contributions to exercise adaptation, we identify specific gaps in knowledge and provide perspectives on future directions of research. Chengdu Sport University 2022-12-08 /pmc/articles/PMC10040379/ /pubmed/36994170 http://dx.doi.org/10.1016/j.smhs.2022.11.005 Text en © 2022 Chengdu Sport University. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Koopmans, Pieter J. Zwetsloot, Kevin A. Murach, Kevin A. Going nuclear: Molecular adaptations to exercise mediated by myonuclei |
title | Going nuclear: Molecular adaptations to exercise mediated by myonuclei |
title_full | Going nuclear: Molecular adaptations to exercise mediated by myonuclei |
title_fullStr | Going nuclear: Molecular adaptations to exercise mediated by myonuclei |
title_full_unstemmed | Going nuclear: Molecular adaptations to exercise mediated by myonuclei |
title_short | Going nuclear: Molecular adaptations to exercise mediated by myonuclei |
title_sort | going nuclear: molecular adaptations to exercise mediated by myonuclei |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040379/ https://www.ncbi.nlm.nih.gov/pubmed/36994170 http://dx.doi.org/10.1016/j.smhs.2022.11.005 |
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