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Going nuclear: Molecular adaptations to exercise mediated by myonuclei

Muscle fibers are multinucleated, and muscle fiber nuclei (myonuclei) are believed to be post-mitotic and are typically situated near the periphery of the myofiber. Due to the unique organization of muscle fibers and their nuclei, the cellular and molecular mechanisms regulating myofiber homeostasis...

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Detalles Bibliográficos
Autores principales: Koopmans, Pieter J., Zwetsloot, Kevin A., Murach, Kevin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chengdu Sport University 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040379/
https://www.ncbi.nlm.nih.gov/pubmed/36994170
http://dx.doi.org/10.1016/j.smhs.2022.11.005
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author Koopmans, Pieter J.
Zwetsloot, Kevin A.
Murach, Kevin A.
author_facet Koopmans, Pieter J.
Zwetsloot, Kevin A.
Murach, Kevin A.
author_sort Koopmans, Pieter J.
collection PubMed
description Muscle fibers are multinucleated, and muscle fiber nuclei (myonuclei) are believed to be post-mitotic and are typically situated near the periphery of the myofiber. Due to the unique organization of muscle fibers and their nuclei, the cellular and molecular mechanisms regulating myofiber homeostasis in unstressed and stressed conditions (e.g., exercise) are unique. A key role myonuclei play in regulating muscle during exercise is gene transcription. Only recently have investigators had the capability to identify molecular changes at high resolution exclusively in myonuclei in response to perturbations in vivo. The purpose of this review is to describe how myonuclei modulate their transcriptome, epigenetic status, mobility and shape, and microRNA expression in response to exercise in vivo. Given the relative paucity of high-fidelity information on myonucleus-specific contributions to exercise adaptation, we identify specific gaps in knowledge and provide perspectives on future directions of research.
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spelling pubmed-100403792023-03-28 Going nuclear: Molecular adaptations to exercise mediated by myonuclei Koopmans, Pieter J. Zwetsloot, Kevin A. Murach, Kevin A. Sports Med Health Sci Review Muscle fibers are multinucleated, and muscle fiber nuclei (myonuclei) are believed to be post-mitotic and are typically situated near the periphery of the myofiber. Due to the unique organization of muscle fibers and their nuclei, the cellular and molecular mechanisms regulating myofiber homeostasis in unstressed and stressed conditions (e.g., exercise) are unique. A key role myonuclei play in regulating muscle during exercise is gene transcription. Only recently have investigators had the capability to identify molecular changes at high resolution exclusively in myonuclei in response to perturbations in vivo. The purpose of this review is to describe how myonuclei modulate their transcriptome, epigenetic status, mobility and shape, and microRNA expression in response to exercise in vivo. Given the relative paucity of high-fidelity information on myonucleus-specific contributions to exercise adaptation, we identify specific gaps in knowledge and provide perspectives on future directions of research. Chengdu Sport University 2022-12-08 /pmc/articles/PMC10040379/ /pubmed/36994170 http://dx.doi.org/10.1016/j.smhs.2022.11.005 Text en © 2022 Chengdu Sport University. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Koopmans, Pieter J.
Zwetsloot, Kevin A.
Murach, Kevin A.
Going nuclear: Molecular adaptations to exercise mediated by myonuclei
title Going nuclear: Molecular adaptations to exercise mediated by myonuclei
title_full Going nuclear: Molecular adaptations to exercise mediated by myonuclei
title_fullStr Going nuclear: Molecular adaptations to exercise mediated by myonuclei
title_full_unstemmed Going nuclear: Molecular adaptations to exercise mediated by myonuclei
title_short Going nuclear: Molecular adaptations to exercise mediated by myonuclei
title_sort going nuclear: molecular adaptations to exercise mediated by myonuclei
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040379/
https://www.ncbi.nlm.nih.gov/pubmed/36994170
http://dx.doi.org/10.1016/j.smhs.2022.11.005
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