Direct activation of KCC2 arrests benzodiazepine refractory status epilepticus and limits the subsequent neuronal injury in mice

Hyperpolarizing GABA(A)R currents, the unitary events that underlie synaptic inhibition, are dependent upon efficient Cl(−) extrusion, a process that is facilitated by the neuronal specific K(+)/Cl(−) co-transporter KCC2. Its activity is also a determinant of the anticonvulsant efficacy of the canon...

Descripción completa

Detalles Bibliográficos
Autores principales: Jarvis, Rebecca, Josephine Ng, Shu Fun, Nathanson, Anna J., Cardarelli, Ross A., Abiraman, Krithika, Wade, Fergus, Evans-Strong, Aidan, Fernandez-Campa, Marina P., Deeb, Tarek Z., Smalley, Joshua L., Jamier, Tanguy, Gurrell, Ian K., McWilliams, Lisa, Kawatkar, Aarti, Conway, Leslie C., Wang, Qi, Burli, Roland W., Brandon, Nicholas J., Chessell, Iain P., Goldman, Aaron J., Maguire, Jamie L., Moss, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040380/
https://www.ncbi.nlm.nih.gov/pubmed/36889319
http://dx.doi.org/10.1016/j.xcrm.2023.100957

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040380/
https://www.ncbi.nlm.nih.gov/pubmed/36889319
http://dx.doi.org/10.1016/j.xcrm.2023.100957

Ejemplares similares