Detection and targeting of splicing deregulation in pediatric acute myeloid leukemia stem cells

Pediatric acute myeloid leukemia (pAML) is typified by high relapse rates and a relative paucity of somatic DNA mutations. Although seminal studies show that splicing factor mutations and mis-splicing fuel therapy-resistant leukemia stem cell (LSC) generation in adults, splicing deregulation has not...

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Detalles Bibliográficos
Autores principales: van der Werf, Inge, Mondala, Phoebe K., Steel, S. Kathleen, Balaian, Larisa, Ladel, Luisa, Mason, Cayla N., Diep, Raymond H., Pham, Jessica, Cloos, Jacqueline, Kaspers, Gertjan J.L., Chan, Warren C., Mark, Adam, La Clair, James J., Wentworth, Peggy, Fisch, Kathleen M., Crews, Leslie A., Whisenant, Thomas C., Burkart, Michael D., Donohoe, Mary E., Jamieson, Catriona H.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040387/
https://www.ncbi.nlm.nih.gov/pubmed/36889320
http://dx.doi.org/10.1016/j.xcrm.2023.100962

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