Engineered cardiac tissue model of restrictive cardiomyopathy for drug discovery

Restrictive cardiomyopathy (RCM) is defined as increased myocardial stiffness and impaired diastolic relaxation leading to elevated ventricular filling pressures. Human variants in filamin C (FLNC) are linked to a variety of cardiomyopathies, and in this study, we investigate an in-frame deletion (c...

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Detalles Bibliográficos
Autores principales: Wang, Bryan Z., Nash, Trevor R., Zhang, Xiaokan, Rao, Jenny, Abriola, Laura, Kim, Youngbin, Zakharov, Sergey, Kim, Michael, Luo, Lori J., Morsink, Margaretha, Liu, Bohao, Lock, Roberta I., Fleischer, Sharon, Tamargo, Manuel A., Bohnen, Michael, Welch, Carrie L., Chung, Wendy K., Marx, Steven O., Surovtseva, Yulia V., Vunjak-Novakovic, Gordana, Fine, Barry M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040415/
https://www.ncbi.nlm.nih.gov/pubmed/36921598
http://dx.doi.org/10.1016/j.xcrm.2023.100976

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