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Sexual behavior shapes male genitourinary microbiome composition

The origin, composition, and significance of the distal male urethral microbiome are unclear, but vaginal microbiome dysbiosis is linked to new sex partners and several urogynecological syndromes. We characterized 110 urethral specimens from men without urethral symptoms, infections, or inflammation...

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Autores principales: Toh, Evelyn, Xing, Yue, Gao, Xiang, Jordan, Stephen J., Batteiger, Teresa A., Batteiger, Byron E., Van Der Pol, Barbara, Muzny, Christina A., Gebregziabher, Netsanet, Williams, James A., Fortenberry, Lora J., Fortenberry, J. Dennis, Dong, Qunfeng, Nelson, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040456/
https://www.ncbi.nlm.nih.gov/pubmed/36948151
http://dx.doi.org/10.1016/j.xcrm.2023.100981
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author Toh, Evelyn
Xing, Yue
Gao, Xiang
Jordan, Stephen J.
Batteiger, Teresa A.
Batteiger, Byron E.
Van Der Pol, Barbara
Muzny, Christina A.
Gebregziabher, Netsanet
Williams, James A.
Fortenberry, Lora J.
Fortenberry, J. Dennis
Dong, Qunfeng
Nelson, David E.
author_facet Toh, Evelyn
Xing, Yue
Gao, Xiang
Jordan, Stephen J.
Batteiger, Teresa A.
Batteiger, Byron E.
Van Der Pol, Barbara
Muzny, Christina A.
Gebregziabher, Netsanet
Williams, James A.
Fortenberry, Lora J.
Fortenberry, J. Dennis
Dong, Qunfeng
Nelson, David E.
author_sort Toh, Evelyn
collection PubMed
description The origin, composition, and significance of the distal male urethral microbiome are unclear, but vaginal microbiome dysbiosis is linked to new sex partners and several urogynecological syndromes. We characterized 110 urethral specimens from men without urethral symptoms, infections, or inflammation using shotgun metagenomics. Most urethral specimens contain characteristic lactic acid bacteria and Corynebacterium spp. In contrast, several bacteria associated with vaginal dysbiosis were present only in specimens from men who reported vaginal intercourse. Sexual behavior, but not other evaluated behavioral, demographic, or clinical variables, strongly associated with inter-specimen variance in urethral microbiome composition. Thus, the male urethra supports a simple core microbiome that is established independent of sexual exposures but can be re-shaped by vaginal sex. Overall, the results suggest that urogenital microbiology and sexual behavior are inexorably intertwined, and show that the male urethra harbors female urogenital pathobionts.
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spelling pubmed-100404562023-03-28 Sexual behavior shapes male genitourinary microbiome composition Toh, Evelyn Xing, Yue Gao, Xiang Jordan, Stephen J. Batteiger, Teresa A. Batteiger, Byron E. Van Der Pol, Barbara Muzny, Christina A. Gebregziabher, Netsanet Williams, James A. Fortenberry, Lora J. Fortenberry, J. Dennis Dong, Qunfeng Nelson, David E. Cell Rep Med Article The origin, composition, and significance of the distal male urethral microbiome are unclear, but vaginal microbiome dysbiosis is linked to new sex partners and several urogynecological syndromes. We characterized 110 urethral specimens from men without urethral symptoms, infections, or inflammation using shotgun metagenomics. Most urethral specimens contain characteristic lactic acid bacteria and Corynebacterium spp. In contrast, several bacteria associated with vaginal dysbiosis were present only in specimens from men who reported vaginal intercourse. Sexual behavior, but not other evaluated behavioral, demographic, or clinical variables, strongly associated with inter-specimen variance in urethral microbiome composition. Thus, the male urethra supports a simple core microbiome that is established independent of sexual exposures but can be re-shaped by vaginal sex. Overall, the results suggest that urogenital microbiology and sexual behavior are inexorably intertwined, and show that the male urethra harbors female urogenital pathobionts. Elsevier 2023-03-21 /pmc/articles/PMC10040456/ /pubmed/36948151 http://dx.doi.org/10.1016/j.xcrm.2023.100981 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Toh, Evelyn
Xing, Yue
Gao, Xiang
Jordan, Stephen J.
Batteiger, Teresa A.
Batteiger, Byron E.
Van Der Pol, Barbara
Muzny, Christina A.
Gebregziabher, Netsanet
Williams, James A.
Fortenberry, Lora J.
Fortenberry, J. Dennis
Dong, Qunfeng
Nelson, David E.
Sexual behavior shapes male genitourinary microbiome composition
title Sexual behavior shapes male genitourinary microbiome composition
title_full Sexual behavior shapes male genitourinary microbiome composition
title_fullStr Sexual behavior shapes male genitourinary microbiome composition
title_full_unstemmed Sexual behavior shapes male genitourinary microbiome composition
title_short Sexual behavior shapes male genitourinary microbiome composition
title_sort sexual behavior shapes male genitourinary microbiome composition
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040456/
https://www.ncbi.nlm.nih.gov/pubmed/36948151
http://dx.doi.org/10.1016/j.xcrm.2023.100981
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