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Periodontitis may predict the use of prescription medicines later in life, a database study

Medications used for the treatment of diseases also affect oral health. We investigated how having/not having periodontitis at baseline in 1985 was associated with purchases of medicines in the long term. The study paradigm is in the oral health-systemic health connections. We hypothesized that peri...

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Autores principales: Frankenhaeuser, Freja, Söder, Birgitta, Källmén, Håkan, Korpi, Esa R., Meurman, Jukka H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040546/
https://www.ncbi.nlm.nih.gov/pubmed/36992840
http://dx.doi.org/10.3389/fphar.2023.1146475
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author Frankenhaeuser, Freja
Söder, Birgitta
Källmén, Håkan
Korpi, Esa R.
Meurman, Jukka H.
author_facet Frankenhaeuser, Freja
Söder, Birgitta
Källmén, Håkan
Korpi, Esa R.
Meurman, Jukka H.
author_sort Frankenhaeuser, Freja
collection PubMed
description Medications used for the treatment of diseases also affect oral health. We investigated how having/not having periodontitis at baseline in 1985 was associated with purchases of medicines in the long term. The study paradigm is in the oral health-systemic health connections. We hypothesized that periodontitis links to purchases of medicines later in life. The study cohort consisted of 3,276 individuals from the greater Stockholm area, Sweden. Of them, 1,655 were clinically examined at baseline. Patients were followed-up for >35 years, using the national population and patient registers. The burden of systemic diseases and purchases of medicines were statistically analyzed comparing patients with (n = 285) and without (n = 1,370) periodontitis. The results showed that patients with periodontitis had purchased more of certain medications than non-periodontitis patients. Periodontitis patients purchased significantly more drugs used in diabetes (p = 0.035), calcium channel blockers (p = 0.016), drugs acting on the renin-angiotensin system (p = 0.024), and nervous system drugs (p = 0.001). Hence, patients with periodontitis indeed had purchased specific medications statistically significantly more than the periodontally healthy ones. This indicates that periodontitis, over time, might increase the risk for systemic diseases with the subsequent need for medication.
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spelling pubmed-100405462023-03-28 Periodontitis may predict the use of prescription medicines later in life, a database study Frankenhaeuser, Freja Söder, Birgitta Källmén, Håkan Korpi, Esa R. Meurman, Jukka H. Front Pharmacol Pharmacology Medications used for the treatment of diseases also affect oral health. We investigated how having/not having periodontitis at baseline in 1985 was associated with purchases of medicines in the long term. The study paradigm is in the oral health-systemic health connections. We hypothesized that periodontitis links to purchases of medicines later in life. The study cohort consisted of 3,276 individuals from the greater Stockholm area, Sweden. Of them, 1,655 were clinically examined at baseline. Patients were followed-up for >35 years, using the national population and patient registers. The burden of systemic diseases and purchases of medicines were statistically analyzed comparing patients with (n = 285) and without (n = 1,370) periodontitis. The results showed that patients with periodontitis had purchased more of certain medications than non-periodontitis patients. Periodontitis patients purchased significantly more drugs used in diabetes (p = 0.035), calcium channel blockers (p = 0.016), drugs acting on the renin-angiotensin system (p = 0.024), and nervous system drugs (p = 0.001). Hence, patients with periodontitis indeed had purchased specific medications statistically significantly more than the periodontally healthy ones. This indicates that periodontitis, over time, might increase the risk for systemic diseases with the subsequent need for medication. Frontiers Media S.A. 2023-03-13 /pmc/articles/PMC10040546/ /pubmed/36992840 http://dx.doi.org/10.3389/fphar.2023.1146475 Text en Copyright © 2023 Frankenhaeuser, Söder, Källmén, Korpi and Meurman. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Frankenhaeuser, Freja
Söder, Birgitta
Källmén, Håkan
Korpi, Esa R.
Meurman, Jukka H.
Periodontitis may predict the use of prescription medicines later in life, a database study
title Periodontitis may predict the use of prescription medicines later in life, a database study
title_full Periodontitis may predict the use of prescription medicines later in life, a database study
title_fullStr Periodontitis may predict the use of prescription medicines later in life, a database study
title_full_unstemmed Periodontitis may predict the use of prescription medicines later in life, a database study
title_short Periodontitis may predict the use of prescription medicines later in life, a database study
title_sort periodontitis may predict the use of prescription medicines later in life, a database study
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040546/
https://www.ncbi.nlm.nih.gov/pubmed/36992840
http://dx.doi.org/10.3389/fphar.2023.1146475
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