Targeting intracellular pathways in idiopathic inflammatory myopathies: A narrative review

In recent decades, several pieces of evidence have drawn greater attention to the topic of innate immunity, in particular, interferon (IFN) and Interleukin 6 in the pathogenesis of idiopathic inflammatory myopathies (IIM). Both of these molecules transduce their signal through a receptor coupled wit...

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Detalles Bibliográficos
Autores principales: La Rocca, Gaetano, Ferro, Francesco, Baldini, Chiara, Libra, Alessandro, Sambataro, Domenico, Colaci, Michele, Malatino, Lorenzo, Palmucci, Stefano, Vancheri, Carlo, Sambataro, Gianluca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040547/
https://www.ncbi.nlm.nih.gov/pubmed/36993798
http://dx.doi.org/10.3389/fmed.2023.1158768
Descripción
Sumario:In recent decades, several pieces of evidence have drawn greater attention to the topic of innate immunity, in particular, interferon (IFN) and Interleukin 6 in the pathogenesis of idiopathic inflammatory myopathies (IIM). Both of these molecules transduce their signal through a receptor coupled with Janus kinases (JAK)/signal transducer and activator of transcription proteins (STAT). In this review, we discuss the role of the JAK/STAT pathway in IIM, evaluate a possible therapeutic role for JAK inhibitors in this group of diseases, focusing on those with the strongest IFN signature (dermatomyositis and antisynthetase syndrome).

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