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Trained immunity: A “new” weapon in the fight against infectious diseases

Innate immune cells can potentiate the response to reinfection through an innate form of immunological memory known as trained immunity. The potential of this fast-acting, nonspecific memory compared to traditional adaptive immunological memory in prophylaxis and therapy has been a topic of great in...

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Autores principales: Dagenais, Amy, Villalba-Guerrero, Carlos, Olivier, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040606/
https://www.ncbi.nlm.nih.gov/pubmed/36993966
http://dx.doi.org/10.3389/fimmu.2023.1147476
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author Dagenais, Amy
Villalba-Guerrero, Carlos
Olivier, Martin
author_facet Dagenais, Amy
Villalba-Guerrero, Carlos
Olivier, Martin
author_sort Dagenais, Amy
collection PubMed
description Innate immune cells can potentiate the response to reinfection through an innate form of immunological memory known as trained immunity. The potential of this fast-acting, nonspecific memory compared to traditional adaptive immunological memory in prophylaxis and therapy has been a topic of great interest in many fields, including infectious diseases. Amidst the rise of antimicrobial resistance and climate change—two major threats to global health—, harnessing the advantages of trained immunity compared to traditional forms of prophylaxis and therapy could be game-changing. Here, we present recent works bridging trained immunity and infectious disease that raise important discoveries, questions, concerns, and novel avenues for the modulation of trained immunity in practice. By exploring the progress in bacterial, viral, fungal, and parasitic diseases, we equally highlight future directions with a focus on particularly problematic and/or understudied pathogens.
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spelling pubmed-100406062023-03-28 Trained immunity: A “new” weapon in the fight against infectious diseases Dagenais, Amy Villalba-Guerrero, Carlos Olivier, Martin Front Immunol Immunology Innate immune cells can potentiate the response to reinfection through an innate form of immunological memory known as trained immunity. The potential of this fast-acting, nonspecific memory compared to traditional adaptive immunological memory in prophylaxis and therapy has been a topic of great interest in many fields, including infectious diseases. Amidst the rise of antimicrobial resistance and climate change—two major threats to global health—, harnessing the advantages of trained immunity compared to traditional forms of prophylaxis and therapy could be game-changing. Here, we present recent works bridging trained immunity and infectious disease that raise important discoveries, questions, concerns, and novel avenues for the modulation of trained immunity in practice. By exploring the progress in bacterial, viral, fungal, and parasitic diseases, we equally highlight future directions with a focus on particularly problematic and/or understudied pathogens. Frontiers Media S.A. 2023-03-13 /pmc/articles/PMC10040606/ /pubmed/36993966 http://dx.doi.org/10.3389/fimmu.2023.1147476 Text en Copyright © 2023 Dagenais, Villalba-Guerrero and Olivier https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Dagenais, Amy
Villalba-Guerrero, Carlos
Olivier, Martin
Trained immunity: A “new” weapon in the fight against infectious diseases
title Trained immunity: A “new” weapon in the fight against infectious diseases
title_full Trained immunity: A “new” weapon in the fight against infectious diseases
title_fullStr Trained immunity: A “new” weapon in the fight against infectious diseases
title_full_unstemmed Trained immunity: A “new” weapon in the fight against infectious diseases
title_short Trained immunity: A “new” weapon in the fight against infectious diseases
title_sort trained immunity: a “new” weapon in the fight against infectious diseases
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040606/
https://www.ncbi.nlm.nih.gov/pubmed/36993966
http://dx.doi.org/10.3389/fimmu.2023.1147476
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