Cargando…

Cross-sectional association between systemic metal concentrations and immune markers in patients with total joint arthroplasty

Total joint arthroplasty (TJA) implants are composed of metal components. Although they are regarded safe, the long-term immunological effects of chronic exposure to the specific implant materials are unknown. We recruited 115 hip and/or knee TJA patients (mean age 68 years) who provided a blood dra...

Descripción completa

Detalles Bibliográficos
Autores principales: Peterson, Stephanie M., O’Byrne, Thomas J., Brennan, Peter C., Jannetto, Paul J., Pavelko, Kevin D., Lewallen, David G., Vassilaki, Maria, Maradit Kremers, Hilal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040609/
https://www.ncbi.nlm.nih.gov/pubmed/36993965
http://dx.doi.org/10.3389/fimmu.2023.1130209
_version_ 1784912513043791872
author Peterson, Stephanie M.
O’Byrne, Thomas J.
Brennan, Peter C.
Jannetto, Paul J.
Pavelko, Kevin D.
Lewallen, David G.
Vassilaki, Maria
Maradit Kremers, Hilal
author_facet Peterson, Stephanie M.
O’Byrne, Thomas J.
Brennan, Peter C.
Jannetto, Paul J.
Pavelko, Kevin D.
Lewallen, David G.
Vassilaki, Maria
Maradit Kremers, Hilal
author_sort Peterson, Stephanie M.
collection PubMed
description Total joint arthroplasty (TJA) implants are composed of metal components. Although they are regarded safe, the long-term immunological effects of chronic exposure to the specific implant materials are unknown. We recruited 115 hip and/or knee TJA patients (mean age 68 years) who provided a blood draw for measurement of chromium, cobalt, titanium concentrations, inflammatory markers and systemic distribution of immune cells. We examined differences between the immune markers and the systemic concentrations of chromium, cobalt and titanium. CD66-b neutrophils, early natural killer cells (NK), and eosinophils were present in higher percentages in patients with chromium and cobalt concentrations greater than the median. The opposite pattern was observed with titanium where the percentages of CD66-b neutrophils, early NK, and eosinophils were higher in patients with undetectable titanium. Cobalt concentrations were positively correlated with a higher percentage of gamma delta T cells. Both chromium and cobalt concentrations were positively correlated with higher percentages of plasmablasts. Titanium concentrations were positively correlated with higher CD4 effector memory T cells, regulatory T cell count and Th1 CD4 helper cells. In this exploratory study, we observed altered distribution of immune cells in TJA patients with elevated systemic metal concentrations. Although these correlations were not strong, these exploratory findings warrant further investigation into the role of increased metals circulating in blood and its role in immune modulation.
format Online
Article
Text
id pubmed-10040609
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-100406092023-03-28 Cross-sectional association between systemic metal concentrations and immune markers in patients with total joint arthroplasty Peterson, Stephanie M. O’Byrne, Thomas J. Brennan, Peter C. Jannetto, Paul J. Pavelko, Kevin D. Lewallen, David G. Vassilaki, Maria Maradit Kremers, Hilal Front Immunol Immunology Total joint arthroplasty (TJA) implants are composed of metal components. Although they are regarded safe, the long-term immunological effects of chronic exposure to the specific implant materials are unknown. We recruited 115 hip and/or knee TJA patients (mean age 68 years) who provided a blood draw for measurement of chromium, cobalt, titanium concentrations, inflammatory markers and systemic distribution of immune cells. We examined differences between the immune markers and the systemic concentrations of chromium, cobalt and titanium. CD66-b neutrophils, early natural killer cells (NK), and eosinophils were present in higher percentages in patients with chromium and cobalt concentrations greater than the median. The opposite pattern was observed with titanium where the percentages of CD66-b neutrophils, early NK, and eosinophils were higher in patients with undetectable titanium. Cobalt concentrations were positively correlated with a higher percentage of gamma delta T cells. Both chromium and cobalt concentrations were positively correlated with higher percentages of plasmablasts. Titanium concentrations were positively correlated with higher CD4 effector memory T cells, regulatory T cell count and Th1 CD4 helper cells. In this exploratory study, we observed altered distribution of immune cells in TJA patients with elevated systemic metal concentrations. Although these correlations were not strong, these exploratory findings warrant further investigation into the role of increased metals circulating in blood and its role in immune modulation. Frontiers Media S.A. 2023-03-13 /pmc/articles/PMC10040609/ /pubmed/36993965 http://dx.doi.org/10.3389/fimmu.2023.1130209 Text en Copyright © 2023 Peterson, O’Byrne, Brennan, Jannetto, Pavelko, Lewallen, Vassilaki and Maradit Kremers https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Peterson, Stephanie M.
O’Byrne, Thomas J.
Brennan, Peter C.
Jannetto, Paul J.
Pavelko, Kevin D.
Lewallen, David G.
Vassilaki, Maria
Maradit Kremers, Hilal
Cross-sectional association between systemic metal concentrations and immune markers in patients with total joint arthroplasty
title Cross-sectional association between systemic metal concentrations and immune markers in patients with total joint arthroplasty
title_full Cross-sectional association between systemic metal concentrations and immune markers in patients with total joint arthroplasty
title_fullStr Cross-sectional association between systemic metal concentrations and immune markers in patients with total joint arthroplasty
title_full_unstemmed Cross-sectional association between systemic metal concentrations and immune markers in patients with total joint arthroplasty
title_short Cross-sectional association between systemic metal concentrations and immune markers in patients with total joint arthroplasty
title_sort cross-sectional association between systemic metal concentrations and immune markers in patients with total joint arthroplasty
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040609/
https://www.ncbi.nlm.nih.gov/pubmed/36993965
http://dx.doi.org/10.3389/fimmu.2023.1130209
work_keys_str_mv AT petersonstephaniem crosssectionalassociationbetweensystemicmetalconcentrationsandimmunemarkersinpatientswithtotaljointarthroplasty
AT obyrnethomasj crosssectionalassociationbetweensystemicmetalconcentrationsandimmunemarkersinpatientswithtotaljointarthroplasty
AT brennanpeterc crosssectionalassociationbetweensystemicmetalconcentrationsandimmunemarkersinpatientswithtotaljointarthroplasty
AT jannettopaulj crosssectionalassociationbetweensystemicmetalconcentrationsandimmunemarkersinpatientswithtotaljointarthroplasty
AT pavelkokevind crosssectionalassociationbetweensystemicmetalconcentrationsandimmunemarkersinpatientswithtotaljointarthroplasty
AT lewallendavidg crosssectionalassociationbetweensystemicmetalconcentrationsandimmunemarkersinpatientswithtotaljointarthroplasty
AT vassilakimaria crosssectionalassociationbetweensystemicmetalconcentrationsandimmunemarkersinpatientswithtotaljointarthroplasty
AT maraditkremershilal crosssectionalassociationbetweensystemicmetalconcentrationsandimmunemarkersinpatientswithtotaljointarthroplasty