Open Thy Lattice Osteoclast, Resorb me!

Osteoclasts degrade bone using Cathepsin K and two metalloproteinases: MMP9 and MMP14. In addition to cleaving collagen, Zhu et al. (2023. J. Cell Biol. https://doi.org/10.1083/jcb.202206121) discover that MMP9 and MMP14 also proteolyze galectin-3 on the cell surface. This process drives a galectin-...

Descripción completa

Detalles Bibliográficos
Autor principal: Bakiri, Latifa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040631/
https://www.ncbi.nlm.nih.gov/pubmed/36928467
http://dx.doi.org/10.1083/jcb.202302033
_version_ 1784912518770065408
author Bakiri, Latifa
author_facet Bakiri, Latifa
author_sort Bakiri, Latifa
collection PubMed
description Osteoclasts degrade bone using Cathepsin K and two metalloproteinases: MMP9 and MMP14. In addition to cleaving collagen, Zhu et al. (2023. J. Cell Biol. https://doi.org/10.1083/jcb.202206121) discover that MMP9 and MMP14 also proteolyze galectin-3 on the cell surface. This process drives a galectin-3/LRP1 signaling axis that supports the hard tissue-resorbing function of osteoclasts.
format Online
Article
Text
id pubmed-10040631
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-100406312023-09-16 Open Thy Lattice Osteoclast, Resorb me! Bakiri, Latifa J Cell Biol Spotlight Osteoclasts degrade bone using Cathepsin K and two metalloproteinases: MMP9 and MMP14. In addition to cleaving collagen, Zhu et al. (2023. J. Cell Biol. https://doi.org/10.1083/jcb.202206121) discover that MMP9 and MMP14 also proteolyze galectin-3 on the cell surface. This process drives a galectin-3/LRP1 signaling axis that supports the hard tissue-resorbing function of osteoclasts. Rockefeller University Press 2023-03-16 /pmc/articles/PMC10040631/ /pubmed/36928467 http://dx.doi.org/10.1083/jcb.202302033 Text en © 2023 Bakiri https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Spotlight
Bakiri, Latifa
Open Thy Lattice Osteoclast, Resorb me!
title Open Thy Lattice Osteoclast, Resorb me!
title_full Open Thy Lattice Osteoclast, Resorb me!
title_fullStr Open Thy Lattice Osteoclast, Resorb me!
title_full_unstemmed Open Thy Lattice Osteoclast, Resorb me!
title_short Open Thy Lattice Osteoclast, Resorb me!
title_sort open thy lattice osteoclast, resorb me!
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040631/
https://www.ncbi.nlm.nih.gov/pubmed/36928467
http://dx.doi.org/10.1083/jcb.202302033
work_keys_str_mv AT bakirilatifa openthylatticeosteoclastresorbme

Ejemplares similares