Fine-tune TMEM11 to unleash basal mitophagy

When mitochondrial damage threatens to disrupt cell and tissue homeostasis, selective autophagy (mitophagy) provides an important route to neutralize dysfunctional organelles. Whilst we understand much about stress-induced mitophagy, steady-state and spatial mechanisms remain elusive. In this issue,...

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Detalles Bibliográficos
Autor principal: McWilliams, Thomas G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040633/
https://www.ncbi.nlm.nih.gov/pubmed/36930241
http://dx.doi.org/10.1083/jcb.202302118
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author McWilliams, Thomas G.
author_facet McWilliams, Thomas G.
author_sort McWilliams, Thomas G.
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description When mitochondrial damage threatens to disrupt cell and tissue homeostasis, selective autophagy (mitophagy) provides an important route to neutralize dysfunctional organelles. Whilst we understand much about stress-induced mitophagy, steady-state and spatial mechanisms remain elusive. In this issue, Gok et al. (2023. J. Cell Biol. https://doi.org/10.1083/jcb.202204021) reveal an unexpected role for TMEM11 in mitophagy regulation.
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spelling pubmed-100406332023-09-17 Fine-tune TMEM11 to unleash basal mitophagy McWilliams, Thomas G. J Cell Biol Spotlight When mitochondrial damage threatens to disrupt cell and tissue homeostasis, selective autophagy (mitophagy) provides an important route to neutralize dysfunctional organelles. Whilst we understand much about stress-induced mitophagy, steady-state and spatial mechanisms remain elusive. In this issue, Gok et al. (2023. J. Cell Biol. https://doi.org/10.1083/jcb.202204021) reveal an unexpected role for TMEM11 in mitophagy regulation. Rockefeller University Press 2023-03-17 /pmc/articles/PMC10040633/ /pubmed/36930241 http://dx.doi.org/10.1083/jcb.202302118 Text en © 2023 McWilliams https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Spotlight
McWilliams, Thomas G.
Fine-tune TMEM11 to unleash basal mitophagy
title Fine-tune TMEM11 to unleash basal mitophagy
title_full Fine-tune TMEM11 to unleash basal mitophagy
title_fullStr Fine-tune TMEM11 to unleash basal mitophagy
title_full_unstemmed Fine-tune TMEM11 to unleash basal mitophagy
title_short Fine-tune TMEM11 to unleash basal mitophagy
title_sort fine-tune tmem11 to unleash basal mitophagy
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040633/
https://www.ncbi.nlm.nih.gov/pubmed/36930241
http://dx.doi.org/10.1083/jcb.202302118
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