Disruption of Ephx2 in cardiomyocytes but not endothelial cells improves functional recovery after ischemia-reperfusion in isolated mouse hearts

Cytochromes P450 metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs) which have numerous effects. After cardiac ischemia, EET-induced coronary vasodilation increases delivery of oxygen/nutrients to the myocardium, and EET-induced signaling protects cardiomyocytes against postischemic mit...

Descripción completa

Detalles Bibliográficos
Autores principales: Edin, Matthew L., Gruzdev, Artiom, Bradbury, J. Alyce, Graves, Joan P., Lih, Fred B., DeGraff, Laura M., Fleming, Ingrid, Zeldin, Darryl C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040734/
https://www.ncbi.nlm.nih.gov/pubmed/36822325
http://dx.doi.org/10.1016/j.jbc.2023.103049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040734/
https://www.ncbi.nlm.nih.gov/pubmed/36822325
http://dx.doi.org/10.1016/j.jbc.2023.103049

Ejemplares similares