Cargando…

Disruption of Ephx2 in cardiomyocytes but not endothelial cells improves functional recovery after ischemia-reperfusion in isolated mouse hearts

Cytochromes P450 metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs) which have numerous effects. After cardiac ischemia, EET-induced coronary vasodilation increases delivery of oxygen/nutrients to the myocardium, and EET-induced signaling protects cardiomyocytes against postischemic mit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Edin, Matthew L., Gruzdev, Artiom, Bradbury, J. Alyce, Graves, Joan P., Lih, Fred B., DeGraff, Laura M., Fleming, Ingrid, Zeldin, Darryl C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040734/ https://www.ncbi.nlm.nih.gov/pubmed/36822325 http://dx.doi.org/10.1016/j.jbc.2023.103049

Ejemplares similares

Generation and characterization of epoxide hydrolase 3 (EPHX3)-deficient mice
por: Hoopes, Samantha L., et al.
Publicado: (2017)

Epoxide hydrolase 3 (Ephx3) gene disruption reduces ceramide linoleate epoxide hydrolysis and impairs skin barrier function
por: Edin, Matthew L., et al.
Publicado: (2021)

The Cytochrome P450 Epoxygenase Pathway Regulates the Hepatic Inflammatory Response in Fatty Liver Disease
por: Schuck, Robert N., et al.
Publicado: (2014)

Pharmacologic Inhibition of COX-1 and COX-2 in Influenza A Viral Infection in Mice
por: Carey, Michelle A., et al.
Publicado: (2010)

Basal and inducible anti-inflammatory epoxygenase activity in endothelial cells
por: Askari, Ara A., et al.
Publicado: (2014)

Vascular Lipidomic Profiling of Potential Endogenous Fatty Acid PPAR Ligands Reveals the Coronary Artery as Major Producer of CYP450-Derived Epoxy Fatty Acids
por: Edin, Matthew L., et al.
Publicado: (2020)

CYP2J2 Overexpression Protects against Arrhythmia Susceptibility in Cardiac Hypertrophy
por: Westphal, Christina, et al.
Publicado: (2013)

The Epoxygenases CYP2J2 Activates the Nuclear Receptor PPARα In Vitro and In Vivo
por: Wray, Jessica A., et al.
Publicado: (2009)

Cardioprotective Effects of Quercetin in Cardiomyocyte under Ischemia/Reperfusion Injury
por: Chen, Yi-Wen, et al.
Publicado: (2013)

Clinical significance of EPHX2 deregulation in prostate cancer
por: Liu, Ming-Sheng, et al.
Publicado: (2020)

Effects of procyanidin on cardiomyocyte apoptosis after myocardial ischemia reperfusion in rats
por: Liu, Dan
Publicado: (2018)

Targeting MIAT reduces apoptosis of cardiomyocytes after ischemia/reperfusion injury
por: Chen, Longying, et al.
Publicado: (2019)

Evidence for the role of EPHX2 gene variants in anorexia nervosa
por: Scott-Van Zeeland, A A, et al.
Publicado: (2014)

Missense Genetic Polymorphisms of Microsomal (EPHX1) and Soluble Epoxide Hydrolase (EPHX2) and Their Relation to the Risk of Large Artery Atherosclerotic Ischemic Stroke in a Turkish Population
por: Can Demirdöğen, Birsen, et al.
Publicado: (2021)

Intimal smooth muscle cells are a source but not a sensor of anti-inflammatory CYP450 derived oxylipins
por: Thomson, Scott, et al.
Publicado: (2015)

Deficiency of Soluble Epoxide Hydrolase Protects Cardiac Function Impaired by LPS-Induced Acute Inflammation
por: Samokhvalov, Victor, et al.
Publicado: (2019)

Human embryonic stem cell-derived cardiomyocyte therapy in mouse permanent ischemia and ischemia-reperfusion models
por: Yu, You, et al.
Publicado: (2019)

Impairment of Endothelial-Myocardial Interaction Increases the Susceptibility of Cardiomyocytes to Ischemia/Reperfusion Injury
por: Leucker, Thorsten M., et al.
Publicado: (2013)

Resveratrol Attenuates Ischemia/Reperfusion Injury in Neonatal Cardiomyocytes and Its Underlying Mechanism
por: Shen, Min, et al.
Publicado: (2012)

Effects of Shenmai injection and its bioactive components following ischemia/reperfusion in cardiomyocytes
por: YE, LI-FANG, et al.
Publicado: (2015)

Inhibition of cardiomyocyte Sprouty1 protects from cardiac ischemia–reperfusion injury
por: Alakoski, Tarja, et al.
Publicado: (2019)

Protective effects of fentanyl preconditioning on cardiomyocyte apoptosis induced by ischemia-reperfusion in rats
por: Xu, Q., et al.
Publicado: (2017)

Cardiomyocyte Damage: Ferroptosis Relation to Ischemia-Reperfusion Injury and Future Treatment Options
por: Laukaitiene, Jolanta, et al.
Publicado: (2023)

Does Disruption of Optic Atrophy-1 (OPA1) Contribute to Cell Death in HL-1 Cardiomyocytes Subjected to Lethal Ischemia-Reperfusion Injury?
por: Kulek, Andrew R., et al.
Publicado: (2022)

Identification and validation of EPHX2 as a prognostic biomarker in hepatocellular carcinoma
por: Zhan, Ke, et al.
Publicado: (2021)

Chymase Mediates Injury and Mitochondrial Damage in Cardiomyocytes during Acute Ischemia/Reperfusion in the Dog
por: Zheng, Junying, et al.
Publicado: (2014)

Pyrrolidinyl caffeamide against ischemia/reperfusion injury in cardiomyocytes through AMPK/AKT pathways
por: Lee, Shih-Yi, et al.
Publicado: (2015)

MicroRNA-93 inhibits ischemia-reperfusion induced cardiomyocyte apoptosis by targeting PTEN
por: Ke, Zun-Ping, et al.
Publicado: (2016)

Penehyclidine hydrochloride post-conditioning reduces ischemia/reperfusion-induced cardiomyocyte apoptosis in rats
por: Tan, Hongbao, et al.
Publicado: (2017)

Obestatin Plays Beneficial Role in Cardiomyocyte Injury Induced by Ischemia-Reperfusion In Vivo and In Vitro
por: Zhang, Qin, et al.
Publicado: (2017)

Follistatin-Like 1 Attenuates Ischemia/Reperfusion Injury in Cardiomyocytes via Regulation of Autophagy
por: Yang, Weijun, et al.
Publicado: (2019)

Histochrome Attenuates Myocardial Ischemia-Reperfusion Injury by Inhibiting Ferroptosis-Induced Cardiomyocyte Death
por: Hwang, Ji-Won, et al.
Publicado: (2021)

Melatonin Attenuates Ischemia/Reperfusion-Induced Oxidative Stress by Activating Mitochondrial Fusion in Cardiomyocytes
por: Ma, Xiaoling, et al.
Publicado: (2022)

Aquaporin 4 inhibition alleviates myocardial ischemia-reperfusion injury by restraining cardiomyocyte pyroptosis
por: Jiang, Qiong, et al.
Publicado: (2021)

Galectin-1 alleviates myocardial ischemia-reperfusion injury by reducing the inflammation and apoptosis of cardiomyocytes
por: Ou, Dengke, et al.
Publicado: (2022)

CTRP12 alleviates cardiomyocyte ischemia-reperfusion injury via regulation of KLF15
por: Liao, Bo, et al.
Publicado: (2022)

Cardiomyocyte-targeted anti-inflammatory nanotherapeutics against myocardial ischemia reperfusion (IR) injury
por: Lan, Min, et al.
Publicado: (2022)

EPHX2 Inhibits Colon Cancer Progression by Promoting Fatty Acid Degradation
por: Zhou, Yiran, et al.
Publicado: (2022)

Proteasome and Organs Ischemia-Reperfusion Injury
por: Oliva, Joan
Publicado: (2017)

CD44 Disruption Attenuates Murine Hepatic Ischemia/Reperfusion Injury
por: Kim, Min Sung, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_448pdgro1lfpad4fi4rdif33kb