Cargando…
The aryl sulfonamide indisulam inhibits gastric cancer cell migration by promoting the ubiquitination and degradation of the transcription factor ZEB1
Gastric cancer is one of the cancers with high morbidity and mortality worldwide. The aryl sulfonamide indisulam inhibits the proliferation of several types of cancer cells through its function as a molecular glue to promote the ubiquitination and degradation of RNA-binding motif protein 39 (RBM39)....
Autores principales: | Lu, Jiaqi, Li, Dan, Jiang, Honglv, Li, Yue, Lu, Chengpiao, Chen, Tao, Wang, Yuhong, Wang, Xiaohui, Sun, Wenzhao, Pu, Zhongjian, Qiao, Chunhua, Ma, Jingjing, Xu, Guoqiang |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040736/ https://www.ncbi.nlm.nih.gov/pubmed/36805336 http://dx.doi.org/10.1016/j.jbc.2023.103025 |
Ejemplares similares
-
A phase I and pharmacokinetic study of indisulam in combination with carboplatin
por: Dittrich, C, et al.
Publicado: (2007) -
Genetic and compound screens uncover factors modulating cancer cell response to indisulam
por: Pogacar, Ziva, et al.
Publicado: (2022) -
Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity
por: Pogacar, Ziva, et al.
Publicado: (2022) -
A dose-escalation study of indisulam in combination with capecitabine (Xeloda) in patients with solid tumours
por: Siegel-Lakhai, W S, et al.
Publicado: (2008) -
Indisulam targets RNA splicing and metabolism to serve as a therapeutic strategy for high-risk neuroblastoma
por: Nijhuis, Anke, et al.
Publicado: (2022)