P2RX7 signaling drives the differentiation of Th1 cells through metabolic reprogramming for aerobic glycolysis

INTRODUCTION: This study provides evidence of how Th1 cell metabolism is modulated by the purinergic receptor P2X7 (P2RX7), a cation cannel activated by high extracellular concentrations of adenosine triphosphate (ATP). METHODS: In vivo analysis was performed in the Plasmodium chabaudi model of mala...

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Detalles Bibliográficos
Autores principales: de Salles, Érika Machado, Raeder, Paulo Lisboa, Angeli, Claudia Blanes, Santiago, Verônica Feijoli, de Souza, Cristiane Naffah, Ramalho, Theresa, Câmara, Niels Olsen Saraiva, Palmisano, Giuseppe, Álvarez, José Maria, D'Império Lima, Maria Regina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040773/
https://www.ncbi.nlm.nih.gov/pubmed/36993971
http://dx.doi.org/10.3389/fimmu.2023.1140426

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