SET7 methylates the deubiquitinase OTUB1 at Lys (122) to impair its binding to E2 enzyme UBC13 and relieve its suppressive role on ferroptosis

The deubiquitinating enzyme OTUB1 possesses canonical deubiquitinase (DUB) activity and noncanonical, catalytic-independent activity, which has been identified as an essential regulator of diverse physiological processes. Posttranslational modifications of OTUB1 affect both its DUB activity and its...

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Detalles Bibliográficos
Autores principales: Deng, Hongyan, Jia, Shuke, Tang, Jinhua, Rong, Fangjing, Xu, Chenxi, Chen, Xiaoyun, Wang, Zixuan, Zhu, Chunchun, Sun, Xueyi, Liao, Qian, Liu, Wen, Li, Wenhua, Xiao, Wuhan, Liu, Xing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040876/
https://www.ncbi.nlm.nih.gov/pubmed/36822329
http://dx.doi.org/10.1016/j.jbc.2023.103054

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