ALK Deletion Exons 2 to 19: Case Report of a Rare ALK Inhibitor–Responsive Lung Cancer Driver Oncogene

ALK internal deletions of nonkinase domain exons occur in 0.01% of lung cancers with ALK genomic aberrations. We report a lung adenocarcinoma with a previously undescribed somatic ALK deletion of exons 2 to 19 with dramatic and sustained (>23 mo) response to alectinib. Our and other reported case...

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Detalles Bibliográficos
Autores principales: Schoepflin, Zachary R., Academia, Emmeline, Osataphan, Soravis A., Rangachari, Deepa, Sharifi, Sheida, VanderLaan, Paul A., Costa, Daniel B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040877/
https://www.ncbi.nlm.nih.gov/pubmed/36994308
http://dx.doi.org/10.1016/j.jtocrr.2023.100489

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