Effectiveness of bronchial thermoplasty in patients with asthma exhibiting overweight/obesity and low quality of life

Bronchial thermoplasty (BT) is effective in some severe asthma patients; however, the specific asthma phenotypes that produce a good response to BT are not fully understood. Clinical data were retrospectively reviewed in severe asthma patients who underwent BT at a single institution in Japan. At th...

Descripción completa

Detalles Bibliográficos
Autores principales: Nishi, Kenta, Yoshimura, Chie, Morita, Kyohei, Ishikawa, Ryoichi, Toyokura, Erika, Nagasaki, Tadao, Matsumoto, Hisako, Nishizaka, Yasuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: World Allergy Organization 2023
Materias:
Correspondence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040894/
https://www.ncbi.nlm.nih.gov/pubmed/36994444
http://dx.doi.org/10.1016/j.waojou.2023.100756
Descripción
Sumario:Bronchial thermoplasty (BT) is effective in some severe asthma patients; however, the specific asthma phenotypes that produce a good response to BT are not fully understood. Clinical data were retrospectively reviewed in severe asthma patients who underwent BT at a single institution in Japan. At the follow-up assessment, the Asthma Quality of Life Questionnaire (AQLQ) scores (P = 0.003), maintenance oral corticosteroid doses (P = 0.027), and exacerbation frequency (P = 0.017) were significantly improved, while prebronchodilator-forced expiratory volume in 1 second (% predicted) did not significantly change (P = 0.19). When we grouped the patients into 2 groups according to their body mass index levels, the AQLQ scores were more improved in patients with overweight/obesity than those with normal weight (P = 0.01). This study showed that patients with non-controlled severe asthma exhibiting overweight/obesity and low quality of life had potential benefits from BT.

Ejemplares similares