Cargando…
Increased SARS-CoV-2 seroprevalence and spread of infection without awareness among healthcare workers through 2020–2022 in a Japanese medical center
Despite Japan’s high vaccination coverage, daily numbers of new COVID-19 cases have been high. However, studies on the seroprevalence among Japanese people and the causative factors for rapid spread have remained limited. In this study, we aimed to examine the seroprevalence and associated factors i...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040914/ https://www.ncbi.nlm.nih.gov/pubmed/36973531 http://dx.doi.org/10.1038/s41598-023-32193-4 |
_version_ | 1784912591522365440 |
---|---|
author | Kanamori, Rie Yan, Yan Ito, Kanami Fukuda, Hiroshi Hori, Satoshi Yamamoto, Takamasa Igawa, Gene Saito, Kaori Horiuchi, Yuki Nojiri, Shuko Nishizaki, Yuji Tabe, Yoko Takahashi, Kazuhisa Naito, Toshio |
author_facet | Kanamori, Rie Yan, Yan Ito, Kanami Fukuda, Hiroshi Hori, Satoshi Yamamoto, Takamasa Igawa, Gene Saito, Kaori Horiuchi, Yuki Nojiri, Shuko Nishizaki, Yuji Tabe, Yoko Takahashi, Kazuhisa Naito, Toshio |
author_sort | Kanamori, Rie |
collection | PubMed |
description | Despite Japan’s high vaccination coverage, daily numbers of new COVID-19 cases have been high. However, studies on the seroprevalence among Japanese people and the causative factors for rapid spread have remained limited. In this study, we aimed to examine the seroprevalence and associated factors in healthcare workers (HCWs) of a medical center in Tokyo using blood samples drawn at annual check-ups from 2020 to 2022. We found that of the 3,788 HCWs in 2022 (by mid-June), 669 were seropositive for N-specific antibodies (tested by Roche Elecsys Anti-SARS-CoV-2 assay); the seroprevalence surged from 0.3% in 2020 and 1.6% in 2021 to 17.7% in 2022. Notably, our study found 325 (48.6%; 325/669) cases were infected without awareness. Among those with a previously PCR-confirmed SARS-CoV-2 infection during the past three years, 79.0% (282/357) were found after January 2022, after the Omicron variant was first detected in Tokyo at the end of 2021. This study indicates the fast spread of the SARS-CoV-2 among HCWs during the Omicron surge in Japan. The high percentage of infection without awareness may be a key driving factor causing rapid person-to-person transmission, as shown in this medical center with high vaccination coverage and strict infection control measures. |
format | Online Article Text |
id | pubmed-10040914 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-100409142023-03-27 Increased SARS-CoV-2 seroprevalence and spread of infection without awareness among healthcare workers through 2020–2022 in a Japanese medical center Kanamori, Rie Yan, Yan Ito, Kanami Fukuda, Hiroshi Hori, Satoshi Yamamoto, Takamasa Igawa, Gene Saito, Kaori Horiuchi, Yuki Nojiri, Shuko Nishizaki, Yuji Tabe, Yoko Takahashi, Kazuhisa Naito, Toshio Sci Rep Article Despite Japan’s high vaccination coverage, daily numbers of new COVID-19 cases have been high. However, studies on the seroprevalence among Japanese people and the causative factors for rapid spread have remained limited. In this study, we aimed to examine the seroprevalence and associated factors in healthcare workers (HCWs) of a medical center in Tokyo using blood samples drawn at annual check-ups from 2020 to 2022. We found that of the 3,788 HCWs in 2022 (by mid-June), 669 were seropositive for N-specific antibodies (tested by Roche Elecsys Anti-SARS-CoV-2 assay); the seroprevalence surged from 0.3% in 2020 and 1.6% in 2021 to 17.7% in 2022. Notably, our study found 325 (48.6%; 325/669) cases were infected without awareness. Among those with a previously PCR-confirmed SARS-CoV-2 infection during the past three years, 79.0% (282/357) were found after January 2022, after the Omicron variant was first detected in Tokyo at the end of 2021. This study indicates the fast spread of the SARS-CoV-2 among HCWs during the Omicron surge in Japan. The high percentage of infection without awareness may be a key driving factor causing rapid person-to-person transmission, as shown in this medical center with high vaccination coverage and strict infection control measures. Nature Publishing Group UK 2023-03-27 /pmc/articles/PMC10040914/ /pubmed/36973531 http://dx.doi.org/10.1038/s41598-023-32193-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Kanamori, Rie Yan, Yan Ito, Kanami Fukuda, Hiroshi Hori, Satoshi Yamamoto, Takamasa Igawa, Gene Saito, Kaori Horiuchi, Yuki Nojiri, Shuko Nishizaki, Yuji Tabe, Yoko Takahashi, Kazuhisa Naito, Toshio Increased SARS-CoV-2 seroprevalence and spread of infection without awareness among healthcare workers through 2020–2022 in a Japanese medical center |
title | Increased SARS-CoV-2 seroprevalence and spread of infection without awareness among healthcare workers through 2020–2022 in a Japanese medical center |
title_full | Increased SARS-CoV-2 seroprevalence and spread of infection without awareness among healthcare workers through 2020–2022 in a Japanese medical center |
title_fullStr | Increased SARS-CoV-2 seroprevalence and spread of infection without awareness among healthcare workers through 2020–2022 in a Japanese medical center |
title_full_unstemmed | Increased SARS-CoV-2 seroprevalence and spread of infection without awareness among healthcare workers through 2020–2022 in a Japanese medical center |
title_short | Increased SARS-CoV-2 seroprevalence and spread of infection without awareness among healthcare workers through 2020–2022 in a Japanese medical center |
title_sort | increased sars-cov-2 seroprevalence and spread of infection without awareness among healthcare workers through 2020–2022 in a japanese medical center |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040914/ https://www.ncbi.nlm.nih.gov/pubmed/36973531 http://dx.doi.org/10.1038/s41598-023-32193-4 |
work_keys_str_mv | AT kanamoririe increasedsarscov2seroprevalenceandspreadofinfectionwithoutawarenessamonghealthcareworkersthrough20202022inajapanesemedicalcenter AT yanyan increasedsarscov2seroprevalenceandspreadofinfectionwithoutawarenessamonghealthcareworkersthrough20202022inajapanesemedicalcenter AT itokanami increasedsarscov2seroprevalenceandspreadofinfectionwithoutawarenessamonghealthcareworkersthrough20202022inajapanesemedicalcenter AT fukudahiroshi increasedsarscov2seroprevalenceandspreadofinfectionwithoutawarenessamonghealthcareworkersthrough20202022inajapanesemedicalcenter AT horisatoshi increasedsarscov2seroprevalenceandspreadofinfectionwithoutawarenessamonghealthcareworkersthrough20202022inajapanesemedicalcenter AT yamamototakamasa increasedsarscov2seroprevalenceandspreadofinfectionwithoutawarenessamonghealthcareworkersthrough20202022inajapanesemedicalcenter AT igawagene increasedsarscov2seroprevalenceandspreadofinfectionwithoutawarenessamonghealthcareworkersthrough20202022inajapanesemedicalcenter AT saitokaori increasedsarscov2seroprevalenceandspreadofinfectionwithoutawarenessamonghealthcareworkersthrough20202022inajapanesemedicalcenter AT horiuchiyuki increasedsarscov2seroprevalenceandspreadofinfectionwithoutawarenessamonghealthcareworkersthrough20202022inajapanesemedicalcenter AT nojirishuko increasedsarscov2seroprevalenceandspreadofinfectionwithoutawarenessamonghealthcareworkersthrough20202022inajapanesemedicalcenter AT nishizakiyuji increasedsarscov2seroprevalenceandspreadofinfectionwithoutawarenessamonghealthcareworkersthrough20202022inajapanesemedicalcenter AT tabeyoko increasedsarscov2seroprevalenceandspreadofinfectionwithoutawarenessamonghealthcareworkersthrough20202022inajapanesemedicalcenter AT takahashikazuhisa increasedsarscov2seroprevalenceandspreadofinfectionwithoutawarenessamonghealthcareworkersthrough20202022inajapanesemedicalcenter AT naitotoshio increasedsarscov2seroprevalenceandspreadofinfectionwithoutawarenessamonghealthcareworkersthrough20202022inajapanesemedicalcenter |