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Atypical Hemolytic Uremic Syndrome Secondary to Pancreatitis: A Case Report

This is a report of an extremely rare case of an atypical hemolytic uremic syndrome (aHUS) that appears to have been triggered by acute pancreatitis. A 68-year-old man was examined at a medical institution because of sudden lower abdominal pain. The patient was diagnosed with acute pancreatitis on c...

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Autores principales: Kajiyama, Tsubasa, Fukuda, Masahumi, Rikitake, Yuuichirou, Takasu, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10041130/
https://www.ncbi.nlm.nih.gov/pubmed/36994293
http://dx.doi.org/10.7759/cureus.35434
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author Kajiyama, Tsubasa
Fukuda, Masahumi
Rikitake, Yuuichirou
Takasu, Osamu
author_facet Kajiyama, Tsubasa
Fukuda, Masahumi
Rikitake, Yuuichirou
Takasu, Osamu
author_sort Kajiyama, Tsubasa
collection PubMed
description This is a report of an extremely rare case of an atypical hemolytic uremic syndrome (aHUS) that appears to have been triggered by acute pancreatitis. A 68-year-old man was examined at a medical institution because of sudden lower abdominal pain. The patient was diagnosed with acute pancreatitis on computed tomography. Hemoglobinuria and laboratory findings indicative of intravascular hemolysis were noted. Biochemical analysis revealed normal results for von Willebrand factor activity, antiplatelet antibodies, and ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13), and stool culture was negative for Shiga-toxin-producing Escherichia coli, leading to the diagnosis of aHUS. Treatment for acute pancreatitis resulted in improvement in the laboratory findings, and the patient’s progress was monitored without treatment intervention for aHUS. On day 2 of hospitalization, the abdominal symptoms and hemoglobinuria resolved without any subsequent recurrence. In the absence of any complications, the patient was transferred back to the initial hospital on day 26 of hospitalization. When hemolytic anemia or thrombocytopenia of unknown etiology is observed, aHUS should be suspected, and clinicians should be aware that acute pancreatitis may be a potential cause of aHUS.
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spelling pubmed-100411302023-03-28 Atypical Hemolytic Uremic Syndrome Secondary to Pancreatitis: A Case Report Kajiyama, Tsubasa Fukuda, Masahumi Rikitake, Yuuichirou Takasu, Osamu Cureus Internal Medicine This is a report of an extremely rare case of an atypical hemolytic uremic syndrome (aHUS) that appears to have been triggered by acute pancreatitis. A 68-year-old man was examined at a medical institution because of sudden lower abdominal pain. The patient was diagnosed with acute pancreatitis on computed tomography. Hemoglobinuria and laboratory findings indicative of intravascular hemolysis were noted. Biochemical analysis revealed normal results for von Willebrand factor activity, antiplatelet antibodies, and ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13), and stool culture was negative for Shiga-toxin-producing Escherichia coli, leading to the diagnosis of aHUS. Treatment for acute pancreatitis resulted in improvement in the laboratory findings, and the patient’s progress was monitored without treatment intervention for aHUS. On day 2 of hospitalization, the abdominal symptoms and hemoglobinuria resolved without any subsequent recurrence. In the absence of any complications, the patient was transferred back to the initial hospital on day 26 of hospitalization. When hemolytic anemia or thrombocytopenia of unknown etiology is observed, aHUS should be suspected, and clinicians should be aware that acute pancreatitis may be a potential cause of aHUS. Cureus 2023-02-24 /pmc/articles/PMC10041130/ /pubmed/36994293 http://dx.doi.org/10.7759/cureus.35434 Text en Copyright © 2023, Kajiyama et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Kajiyama, Tsubasa
Fukuda, Masahumi
Rikitake, Yuuichirou
Takasu, Osamu
Atypical Hemolytic Uremic Syndrome Secondary to Pancreatitis: A Case Report
title Atypical Hemolytic Uremic Syndrome Secondary to Pancreatitis: A Case Report
title_full Atypical Hemolytic Uremic Syndrome Secondary to Pancreatitis: A Case Report
title_fullStr Atypical Hemolytic Uremic Syndrome Secondary to Pancreatitis: A Case Report
title_full_unstemmed Atypical Hemolytic Uremic Syndrome Secondary to Pancreatitis: A Case Report
title_short Atypical Hemolytic Uremic Syndrome Secondary to Pancreatitis: A Case Report
title_sort atypical hemolytic uremic syndrome secondary to pancreatitis: a case report
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10041130/
https://www.ncbi.nlm.nih.gov/pubmed/36994293
http://dx.doi.org/10.7759/cureus.35434
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