EMBER multidimensional spectral microscopy enables quantitative determination of disease- and cell-specific amyloid strains

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In neurodegenerative diseases, proteins fold into amyloid structures with distinct conformations (strains) that are characteristic of different diseases. However, there is a need to rapidly identify amyloid conformations in situ. Here, we use machine learning on the full information available in flu...

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Detalles Bibliográficos
Autores principales: Yang, Hyunjun, Yuan, Peng, Wu, Yibing, Shi, Marie, Caro, Christoffer D., Tengeiji, Atsushi, Yamanoi, Shigeo, Inoue, Masahiro, DeGrado, William F., Condello, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10041141/
https://www.ncbi.nlm.nih.gov/pubmed/36927157
http://dx.doi.org/10.1073/pnas.2300769120
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