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Accumulation of pTau231 at the Postsynaptic Density in Early Alzheimer’s Disease

BACKGROUND: Phosphorylated cytoplasmic tau inclusions correlate with and precede cognitive deficits in Alzheimer’s disease (AD). However, pathological tau accumulation and relationships to synaptic changes remain unclear. OBJECTIVE: To address this, we examined postmortem brain from 50 individuals w...

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Detalles Bibliográficos
Autores principales:	Lilek, Jaclyn, Ajroud, Kaouther, Feldman, Alexander Z., Krishnamachari, Sesha, Ghourchian, Shadi, Gefen, Tamar, Spencer, Callen L., Kawles, Allegra, Mao, Qinwen, Tranovich, Jessica F., Jack, Clifford R., Mesulam, M-Marsel, Reichard, R. Ross, Zhang, Hui, Murray, Melissa E., Knopman, David, Dickson, Dennis W., Petersen, Ronald C., Smith, Benjamin, Ashe, Karen H., Mielke, Michelle M., Nelson, Kathryn M., Flanagan, Margaret E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10041451/ https://www.ncbi.nlm.nih.gov/pubmed/36744338 http://dx.doi.org/10.3233/JAD-220848

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